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Blood, 1 December 2006, Vol. 108, No. 12, pp. 3913-3915. Prepublished online as a Blood First Edition Paper on August 15, 2006; DOI 10.1182/blood-2006-03-008805. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-03-008805v1 108/12/3913    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Moliterno, A. R. Articles by Spivak, J. L. Search for Related Content PubMed PubMed Citation Articles by Moliterno, A. R. Articles by Spivak, J. L. Related Collections Neoplasia Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression Alison R. Moliterno, Donna M. Williams, Ophelia Rogers, and Jerry L. Spivak From the Johns Hopkins University School of Medicine, Baltimore, MD. An activating JAK2 mutation (JAK2 V617F) is present in the chronic myeloproliferative disorders (MPDs), polycythemia vera (PV), idiopathic myelofibrosis (IMF), and essential thrombocytosis (ET). JAK2 is also a chaperone for Mpl and responsible for its cell-surface expression. We observed a reciprocal relationship between neutrophil JAK2 V617F allele percentage and platelet Mpl expression in JAK2 V617F–positive PV, IMF, and ET patients. However, severely impaired platelet Mpl expression was present in JAK2 V617F–negative MPD patients. While JAK2 V617F allele status did not necessarily correlate with the clinical MPD phenotype, the degree of impaired platelet Mpl expression did. We conclude that multiple molecular abnormalities are involved in the pathogenesis of the MPDs and that aberrant Mpl expression may be a common denominator of aberrant signaling in both the JAK2 V617F–positive and JAK2 V617F–negative MPDs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Provan, C. R.J. Singer, T. Baglin, and I. Dokal Pathogenesis of the MPNs Oxford Handbook of Clinical Haematology, March 18, 2010; 3(1): med-9780199227396-div1-10 - med-9780199227396-div1-10. [Full Text] D. Provan, C. R.J. Singer, T. Baglin, and I. Dokal Essential thrombocythaemia (ET) Oxford Handbook of Clinical Haematology, March 18, 2010; 3(1): med-9780199227396-div1-11 - med-9780199227396-div1-11. [Full Text] J. L. Spivak Narrative Review: Thrombocytosis, Polycythemia Vera, and JAK2 Mutations: The Phenotypic Mimicry of Chronic Myeloproliferation Ann Intern Med, March 2, 2010; 152(5): 300 - 306. [Abstract] [Full Text] [PDF] M. L. Randi, A. M. Brunati, M. Scapin, M. Frasson, R. Deana, E. Magrin, F. Fabris, and A. Donella-Deana Src tyrosine kinase preactivation is associated with platelet hypersensitivity in essential thrombocythemia and polycythemia vera Blood, January 21, 2010; 115(3): 667 - 676. [Abstract] [Full Text] [PDF] Z. Ye, H. Zhan, P. Mali, S. Dowey, D. M. Williams, Y.-Y. Jang, C. V. Dang, J. L. Spivak, A. R. Moliterno, and L. Cheng Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders Blood, December 24, 2009; 114(27): 5473 - 5480. [Abstract] [Full Text] [PDF] R. Tiedt, J. Coers, S. Ziegler, A. Wiestner, H. Hao-Shen, C. Bornmann, J. Schenkel, S. Karakhanova, F. J. de Sauvage, C. W. Jackson, et al. Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes Blood, February 19, 2009; 113(8): 1768 - 1777. [Abstract] [Full Text] [PDF] F. Passamonti and E. Rumi Clinical relevance of JAK2 (V617F) mutant allele burden Haematologica, January 1, 2009; 94(1): 7 - 10. [Full Text] [PDF] R. C. Skoda Thrombocytosis Hematology, January 1, 2009; 2009(1): 159 - 167. [Abstract] [Full Text] [PDF] F. Passamonti, E. Rumi, L. Arcaini, E. Boveri, C. Elena, D. Pietra, S. Boggi, C. Astori, P. Bernasconi, M. Varettoni, et al. Prognostic factors for thrombosis, myelofibrosis, and leukemia in essential thrombocythemia: a study of 605 patients Haematologica, November 1, 2008; 93(11): 1645 - 1651. [Abstract] [Full Text] [PDF] N. Fourouclas, J. Li, D. C. Gilby, P. J. Campbell, P. A. Beer, E. M. Boyd, A. C. Goodeve, D. Bareford, C. N. Harrison, J. T. Reilly, et al. Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders Haematologica, November 1, 2008; 93(11): 1635 - 1644. [Abstract] [Full Text] [PDF] J. L. Spivak and R. T. Silver The revised World Health Organization diagnostic criteria for polycythemia vera, essential thrombocytosis, and primary myelofibrosis: an alternative proposal Blood, July 15, 2008; 112(2): 231 - 239. [Full Text] [PDF] R. Tiedt, H. Hao-Shen, M. A. Sobas, R. Looser, S. Dirnhofer, J. Schwaller, and R. C. Skoda Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice Blood, April 15, 2008; 111(8): 3931 - 3940. [Abstract] [Full Text] [PDF] C. James The JAK2V617F Mutation in Polycythemia Vera and Other Myeloproliferative Disorders: One Mutation for Three Diseases? Hematology, January 1, 2008; 2008(1): 69 - 75. [Abstract] [Full Text] [PDF] R. L. Levine and M. Heaney New Advances in the Pathogenesis and Therapy of Essential Thrombocythemia Hematology, January 1, 2008; 2008(1): 76 - 82. [Abstract] [Full Text] [PDF] E. Rumi, F. Passamonti, M. G. Della Porta, C. Elena, L. Arcaini, L. Vanelli, C. Del Curto, D. Pietra, E. Boveri, C. Pascutto, et al. Familial Chronic Myeloproliferative Disorders: Clinical Phenotype and Evidence of Disease Anticipation J. Clin. Oncol., December 10, 2007; 25(35): 5630 - 5635. [Abstract] [Full Text] [PDF] J. L. Spivak Thrombocytosis, pregnancy, and regression toward mean Blood, July 15, 2007; 110(2): 472 - 473. [Full Text] [PDF] F. Passamonti, M. L. Randi, E. Rumi, E. Pungolino, C. Elena, D. Pietra, M. Scapin, L. Arcaini, F. Tezza, R. Moratti, et al. Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V>F) mutation Blood, July 15, 2007; 110(2): 485 - 489. [Abstract] [Full Text] [PDF] E. Hammond, K. Shaw, B. Carnley, S. P'ng, I. James, and R. Herrmann Quantitative Determination of JAK2 V617F by TaqMan: An Absolute Measure of Averaged Copies per Cell That May Be Associated with the Different Types of Myeloproliferative Disorders J. Mol. Diagn., April 1, 2007; 9(2): 242 - 248. [Abstract] [Full Text] [PDF] A. M. Vannucchi and T. Barbui Thrombocytosis and Thrombosis Hematology, January 1, 2007; 2007(1): 363 - 370. [Abstract] [Full Text] [PDF]

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