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Blood, 15 December 2006, Vol. 108, No. 13, pp. 4163-4169. Prepublished online as a Blood First Edition Paper on August 10, 2006; DOI 10.1182/blood-2006-04-017632. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-04-017632v1 108/13/4163    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dupuis, J. Articles by Gaulard, P. Search for Related Content PubMed PubMed Citation Articles by Dupuis, J. Articles by Gaulard, P. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Prognostic significance of Epstein-Barr virus in nodal peripheral T-cell lymphoma, unspecified: a Groupe d'Etude des Lymphomes de l'Adulte (GELA) study Jehan Dupuis, Jean-François Emile, Nicolas Mounier, Christian Gisselbrecht, Nadine Martin-Garcia, Tony Petrella, Reda Bouabdallah, Françoise Berger, Alain Delmer, Bertrand Coiffier, Félix Reyes, and Philippe Gaulard From the Department of Hematology, the Department of Pathology, and the Institut National de la Santé et de la Recherche Médicale (INSERM) U617 Hôpital Henri Mondor, Créteil; the Department of Pathology, Hôpital Ambroise Paré, Boulogne; the Department of Pathology, Dijon University Hospital; the Department of Hematology, Institut Paoli-Calmettes, Marseille; the Department of Pathology, Centre Hospitalier Lyon-Sud, Pierre-Bénite; the Department of Hematology, Hôtel Dieu, Paris; and the Department of Hematology, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France. Peripheral T-cell lymphomas (PTCLs) are rare and have a dismal prognosis. The most frequent subtype is PTCL, unspecified. Epstein-Barr virus (EBV) has been detected in around 40% of cases, but its prognostic significance is not fully established. Lymph node samples from 110 patients with PTCL, unspecified included in LNH87 and LNH93 trials were available. EBV status was studied by EBV-encoded small RNA in situ hybridization (EBER-ISH). EBER-ISH showed positive cells in 45 (41%) of 110 patients. Pretreatment characteristics were comparable between positive and negative cases, except for male sex (80% versus 60%, respectively, P = .02). Only 50% of patients achieved complete remission with a 5-year event-free survival (EFS) and overall survival (OS) of 21% and 30%, respectively. EBER-ISH positivity was the sole factor linked with worse EFS, with a 5-year probability of 11% for positive patients. In univariate analysis, factors affecting OS were EBER-ISH positivity, high LDH level, and age older than 60 years. In multivariate analysis, EBER-ISH was associated with a worse OS in the elderly population. Time-dependent analysis showed that the negative impact of EBV was essentially seen in the first 2 years following diagnosis. These results warrant further studies regarding pathogenesis and specific treatment approaches for EBV-associated PTCL patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. L. Gulley and W. Tang Laboratory Assays for Epstein-Barr Virus-Related Disease J. Mol. Diagn., July 1, 2008; 10(4): 279 - 292. [Abstract] [Full Text] [PDF] S. Park, J. Lee, Y. H. Ko, A. Han, H. J. Jun, S. C. Lee, I. G. Hwang, Y. H. Park, J. S. Ahn, C. W. Jung, et al. The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma Blood, August 1, 2007; 110(3): 972 - 978. [Abstract] [Full Text] [PDF]

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