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 Blood, 15 December 2006, Vol. 108, No. 13, pp. 4194-4197.
Prepublished online as a Blood First Edition Paper on August 31, 2006; DOI 10.1182/blood-2006-06-029355.

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NEOPLASIA
Brief report

CD200 is a new prognostic factor in multiple myeloma

Jerome Moreaux, Dirk Hose, Thierry Reme, Eric Jourdan, Michael Hundemer, Eric Legouffe, Philippe Moine, Philippe Bourin, Marion Moos, Jill Corre, Thomas Möhler, John De Vos, Jean Francois Rossi, Hartmut Goldschmidt, and Bernard Klein

From the Centre Hospitalier Universitaire (CHU) Montpellier, Department of Hematology and Clinical Oncology and Institute of Research in Biotherapy, Montpellier, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U475, Montpellier, France; Medizinische Klinik und Poliklinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany; CHU Nimes, Internal Medicine Department B, Nimes, France; Laboratoire de Thérapie Cellulaire-Etablissement Français du sang, Pyrénées-Méditerranée, Toulouse, France; Université Montpellier 1, Unité de Formation et de Recherche (UFR) Médecine, Montpellier, France; and Nationales Centrum für Tumorerkrankungen, Heidelberg, Germany.

Using Affymetrix microarrays, we identified the expression of the CD200 gene in multiple myeloma cells (MMCs) of 112 patients with newly diagnosed multiple myeloma (MM). The CD200 gene was either absent or present (Affymetrix call) in 22% and 78% of MMCs, respectively. The CD200 gene is not expressed in cells of the patients' bone marrow (BM). CD200 is a membrane glycoprotein that imparts an immunoregulatory signal through CD200R, leading to the suppression of T-cell–mediated immune responses. Patients with CD200absent MMCs have an increased event-free survival (EFS; 24 months) compared with patients with CD200present MMCs (14 months), after high-dose therapy and stem cell transplantation. In a Cox proportional-hazard model, the absence or presence of CD200 expression in MMCs is predictive for EFS for patients independently of ISS stage or beta2M serum levels. Thus, CD200 is an independent prognosis factor for patients with MM that could represent a new therapeutic target in MM.


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