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Blood, 15 July 2006, Vol. 108, No. 2, pp. 426-431. Prepublished online as a Blood First Edition Paper on March 14, 2006; DOI 10.1182/blood-2006-01-0177. This Article Full Text Full Text (PDF) Erratum (v112,p3530) All Versions of this Article: 2006-01-0177v1 108/2/426    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wei, S. Articles by Zou, W. Search for Related Content PubMed PubMed Citation Articles by Wei, S. Articles by Zou, W. Related Collections Immunobiology Transplantation Free Research Articles Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES Regulatory T-cell compartmentalization and trafficking Shuang Wei, Ilona Kryczek, and Weiping Zou From the Department of Surgery, University of Michigan, Ann Arbor. CD4+CD25+FOXP3+ regulatory T cells (CD4+ Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-presenting cells (APCs) and T cells, is crucial for ensuring suppression by Treg cells in the appropriate microenvironment. Emerging evidence suggests that Treg compartmentalization and trafficking may be tissue or/and organ specific and that distinct chemokine receptor and integrin expression may contribute to selective retention and trafficking of Treg cells at sites where regulation is required. In this review, the cellular and molecular signals that control specialized migration and retention of Treg cells are discussed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. M. Laabs, W. Wu, and S. Mendez Vaccination with Live Leishmania major and CpG DNA Promotes Interleukin-2 Production by Dermal Dendritic Cells and NK Cell Activation Clin. Vaccine Immunol., November 1, 2009; 16(11): 1601 - 1606. [Abstract] [Full Text] [PDF] D. Soler, T. Chapman, L.-L. Yang, T. Wyant, R. Egan, and E. R. 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