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 Blood, 15 July 2006, Vol. 108, No. 2, pp. 515-517.
Prepublished online as a Blood First Edition Paper on March 28, 2006; DOI 10.1182/blood-2005-11-4571.

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Brief report

FVIII production by human lung microvascular endothelial cells

Marc Jacquemin, Arne Neyrinck, Maria Iris Hermanns, Renaud Lavend'homme, Filip Rega, Jean-Marie Saint-Remy, Kathelijne Peerlinck, Dirk Van Raemdonck, and Charles James Kirkpatrick

From the Center for Molecular and Vascular Biology, University of Leuven, Belgium; Institute of Pathology, Johannes Gutenberg University, Mainz, Germany; and the Laboratory for Experimental Thoracic Surgery, Katholieke Universiteit Leuven, Belgium.

While extrahepatic factor VIII (FVIII) synthesis suffices for hemostasis, the extrahepatic production sites are not well defined. We therefore investigated the ability of the human lungs to produce FVIII. Lungs from heart-beating donors who were declined for transplantation were perfused and ventilated in an isolated reperfusion model for 2 hours. A progressive accumulation of FVIII and von Willebrand factor (VWF) was recorded in the perfusion medium in 3 of 4 experiments. By contrast, factor V, fibrinogen, and immunoglobulin G (IgG) levels remained constant during the perfusion period, indicating that the accumulation of FVIII and VWF was not due to diffusion from the intercellular medium into the vascular system. Purified human lung microvascular endothelial cells produced FVIII during at least 2 passages in vitro. Altogether, these data identify the lung endothelial cells as a FVIII production site in humans.


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Related Article in Blood Online:

Factor VIII biosynthesis: new inspirations?
Jay Lozier
Blood 2006 108: 414-415. [Full Text] [PDF]





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