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 Blood, 15 July 2006, Vol. 108, No. 2, pp. 559-565.
Prepublished online as a Blood First Edition Paper on March 23, 2006; DOI 10.1182/blood-2005-07-007096.

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IMMUNOBIOLOGY

Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis

Inna N. Lavrik, Alexander Golks, Simone Baumann, and Peter H. Krammer

From the Division of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany.

Caspase-2 was reported to be involved in a number of apoptotic pathways triggered by various stimuli. However, the molecular mechanism of procaspase-2 activation in the course of apoptosis remains poorly defined. In this report, we demonstrate that procaspase-2 is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex (DISC) in human T- and B-cell lines. We show that procaspase-2 is activated at the DISC on CD95 stimulation. Despite its presence at the DISC, caspase-2 does not initiate apoptosis on CD95 stimulation in caspase-8–deficient cell lines. Taken together, our data reveal that caspase-2 is activated at the DISC but does not play an initiating role in the CD95-induced apoptosis.


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