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Blood, 15 July 2006, Vol. 108, No. 2, pp. 575-583. Prepublished online as a Blood First Edition Paper on March 23, 2006; DOI 10.1182/blood-2005-04-1485. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-04-1485v1 108/2/575    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hassanzadeh Ghassabeh, G. Articles by Raes, G. Search for Related Content PubMed PubMed Citation Articles by Hassanzadeh Ghassabeh, G. Articles by Raes, G. Related Collections Immunobiology Phagocytes Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Identification of a common gene signature for type II cytokine–associated myeloid cells elicited in vivo in different pathologic conditions Gholamreza Hassanzadeh Ghassabeh, Patrick De Baetselier, Lea Brys, Wim Noël, Jo A. Van Ginderachter, Sofie Meerschaut, Alain Beschin, Frank Brombacher, and Geert Raes From the Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Brussels, Belgium; and the Health Sciences Faculty, University of Cape Town, South Africa. Compared with type I cytokine–associated myeloid (M1) cells, the molecular repertoire and mechanisms underlying functional properties of type II cytokine–associated myeloid (M2) cells are poorly characterized. Moreover, most studies have been limited to in vitro–elicited M2 cells. Here, comparative gene expression profiling of M1 and M2 cells, elicited in murine models of parasitic infections and cancer, yielded a common signature for in vivo–induced M2 populations independent of disease model, mouse strain, and organ source of cells. Some of these genes, such as cadherin-1, selenoprotein P, platelet-activating factor acetylhydrolase, and prosaposin, had not been documented as associated with M2. Overall, the common signature genes provide a molecular basis for a number of documented or suggested properties of M2, including immunomodulation, down-regulation of inflammation, protection against oxidative damage, high capacity for phagocytosis, and tissue repair. Interestingly, several common M2 signature genes encode membrane-associated markers that could be useful for the identification and isolation of M2. Some of these genes were not induced by IL-4/IL-13 or IL-10 under various in vitro settings and thus were missed in approaches based on in vitro–activated cells, validating our choice of in vivo models for expression profiling of myeloid cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Macrophage diversity and polarization: in vivo veritas Alberto Mantovani Blood 2006 108: 408-409. [Full Text] [PDF] This article has been cited by other articles: T. Bosschaerts, M. Guilliams, W. Noel, M. Herin, R. F. Burk, K. E. Hill, L. Brys, G. Raes, G. H. Ghassabeh, P. De Baetselier, et al. Alternatively Activated Myeloid Cells Limit Pathogenicity Associated with African Trypanosomiasis through the IL-10 Inducible Gene Selenoprotein P J. Immunol., May 1, 2008; 180(9): 6168 - 6175. [Abstract] [Full Text] [PDF] S. K. Biswas, A. Sica, and C. E. Lewis Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms J. Immunol., February 15, 2008; 180(4): 2011 - 2017. [Abstract] [Full Text] [PDF] C.-S. Chiang, F.-H. Chen, J.-H. Hong, P.-S. Jiang, H.-L. Huang, C.-C. Wang, and W. H. McBride Functional phenotype of macrophages depends on assay procedures Int. Immunol., February 1, 2008; 20(2): 215 - 222. [Abstract] [Full Text] [PDF] B. Stijlemans, T. N. Baral, M. Guilliams, L. Brys, J. Korf, M. Drennan, J. Van Den Abbeele, P. De Baetselier, and S. Magez A Glycosylphosphatidylinositol-Based Treatment Alleviates Trypanosomiasis-Associated Immunopathology J. Immunol., September 15, 2007; 179(6): 4003 - 4014. [Abstract] [Full Text] [PDF] M. Guilliams, G. Oldenhove, W. Noel, M. Herin, L. Brys, P. Loi, V. Flamand, M. Moser, P. De Baetselier, and A. Beschin African Trypanosomiasis: Naturally Occurring Regulatory T Cells Favor Trypanotolerance by Limiting Pathology Associated with Sustained Type 1 Inflammation J. Immunol., September 1, 2007; 179(5): 2748 - 2757. [Abstract] [Full Text] [PDF] C. Auffray, D. Fogg, M. Garfa, G. Elain, O. Join-Lambert, S. Kayal, S. Sarnacki, A. Cumano, G. Lauvau, and F. Geissmann Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior Science, August 3, 2007; 317(5838): 666 - 670. [Abstract] [Full Text] [PDF] G. Caljon, J. Van Den Abbeele, B. Stijlemans, M. Coosemans, P. De Baetselier, and S. Magez Tsetse Fly Saliva Accelerates the Onset of Trypanosoma brucei Infection in a Mouse Model Associated with a Reduced Host Inflammatory Response Infect. Immun., November 1, 2006; 74(11): 6324 - 6330. [Abstract] [Full Text] [PDF] J. A. Van Ginderachter, S. Meerschaut, Y. Liu, L. Brys, K. De Groeve, G. Hassanzadeh Ghassabeh, G. Raes, and P. De Baetselier Peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer Blood, July 15, 2006; 108(2): 525 - 535. [Abstract] [Full Text] [PDF]

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