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Blood, 15 July 2006, Vol. 108, No. 2, pp. 600-608. Prepublished online as a Blood First Edition Paper on April 4, 2006; DOI 10.1182/blood-2005-12-4827. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-12-4827v1 2005-12-4827v2 108/2/600    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cornish, G. H. Articles by Cantrell, D. A. Search for Related Content PubMed PubMed Citation Articles by Cornish, G. H. Articles by Cantrell, D. A. Related Collections Immunobiology Cell Cycle Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Differential regulation of T-cell growth by IL-2 and IL-15 Georgina H. Cornish, Linda V. Sinclair, and Doreen A. Cantrell From Cancer Research UK, London, England; the Edward Jenner Institute for Vaccine Research, Berkshire, England; and the School of Life Sciences, University of Dundee, Scotland. Although interleukin 2 (IL-2) and IL-15 signal through the common gamma chain (c) and through IL-2 receptor –chain (CD122) subunits, they direct distinct physiologic and immunotherapeutic responses in T cells. The present study provides some insight into why IL-2 and IL-15 differentially regulate T-cell function by revealing that these cytokines are strikingly distinct in their ability to control protein synthesis and T-cell mass. IL-2 and IL-15 are shown to be equivalent mitogens for antigen-stimulated CD8+ T cells but not for equivalent growth factors. Antigen-primed T cells cannot autonomously maintain amino acid incorporation or de novo protein synthesis without exogenous cytokine stimulation. Both IL-2 and IL-15 induce amino acid uptake and protein synthesis in antigen-activated T cells; however, the IL-2 response is strikingly more potent than the IL-15 response. The differential action of IL-2 and IL-15 on amino acid uptake and protein synthesis is explained by temporal differences in signaling induced by these 2 cytokines. Hence, the present results show that cytokines that are equivalent mitogens can have different potency in terms of regulating protein synthesis and cell growth. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Time to restore individual rights for IL-2 and IL-15? Yutaka Tagaya Blood 2006 108: 409-410. [Full Text] [PDF] This article has been cited by other articles: M. Terabe, Y. Tagaya, Q. Zhu, L. Granger, M. Roederer, T. A. Waldmann, and J. A. Berzofsky IL-15 Expands Unconventional CD8{alpha}{alpha}NK1.1+ T Cells but Not V{alpha}14J{alpha}18+ NKT Cells J. Immunol., June 1, 2008; 180(11): 7276 - 7286. [Abstract] [Full Text] [PDF] M. J. Lindemann, Z. Hu, M. Benczik, K. D. Liu, and S. L. Gaffen Differential Regulation of the IL-17 Receptor by {gamma}c Cytokines: INHIBITORY SIGNALING BY THE PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY J. Biol. Chem., May 16, 2008; 283(20): 14100 - 14108. [Abstract] [Full Text] [PDF] M. Marzec, K. Halasa, M. Kasprzycka, M. Wysocka, X. Liu, J. W. Tobias, D. Baldwin, Q. Zhang, N. Odum, A. H. Rook, et al. Differential Effects of Interleukin-2 and Interleukin-15 versus Interleukin-21 on CD4+ Cutaneous T-Cell Lymphoma Cells Cancer Res., February 15, 2008; 68(4): 1083 - 1091. [Abstract] [Full Text] [PDF] M. Marzec, X. Liu, M. Kasprzycka, A. Witkiewicz, P. N. Raghunath, M. El-Salem, E. Robertson, N. Odum, and M. A. Wasik IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes Blood, February 15, 2008; 111(4): 2181 - 2189. [Abstract] [Full Text] [PDF] J.-H. Cho, O. Boyman, H.-O. Kim, B. Hahm, M. P. Rubinstein, C. Ramsey, D. M. Kim, C. D. Surh, and J. Sprent An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2 J. Exp. Med., August 6, 2007; 204(8): 1787 - 1801. [Abstract] [Full Text] [PDF] N. Sato, H. J. Patel, T. A. Waldmann, and Y. Tagaya The IL-15/IL-15R{alpha} on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells PNAS, January 9, 2007; 104(2): 588 - 593. [Abstract] [Full Text] [PDF] C. Eidenschenk, E. Jouanguy, A. Alcais, J.-J. Mention, B. Pasquier, I. M. Fleckenstein, A. Puel, L. Gineau, J.-C. Carel, E. Vivier, et al. Familial NK Cell Deficiency Associated with Impaired IL-2- and IL-15-Dependent Survival of Lymphocytes J. Immunol., December 15, 2006; 177(12): 8835 - 8843. [Abstract] [Full Text] [PDF] P. Tamas, S. A. Hawley, R. G. Clarke, K. J. Mustard, K. Green, D. G. Hardie, and D. A. Cantrell Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes J. Exp. Med., July 10, 2006; 203(7): 1665 - 1670. [Abstract] [Full Text] [PDF]

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