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Blood, 1 August 2006, Vol. 108, No. 3, pp. 1073-1076. Prepublished online as a Blood First Edition Paper on March 30, 2006; DOI 10.1182/blood-2005-09-008318. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2005-09-008318v1 108/3/1073    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Franco, R. S. Articles by Rucknagel, D. L. Search for Related Content PubMed PubMed Citation Articles by Franco, R. S. Articles by Rucknagel, D. L. Related Collections Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS The effect of fetal hemoglobin on the survival characteristics of sickle cells Robert S. Franco, Zahida Yasin, Mary B. Palascak, Peter Ciraolo, Clinton H. Joiner, and Donald L. Rucknagel From the Division of Hematology/Oncology, Division of Pediatric Hematology/Oncology, and Cincinnati Comprehensive Sickle Cell Center, University of Cincinnati, OH. The determinants of sickle red blood cell (RBC) life span have not been well-defined but may include both intrinsic factors (eg, the tendency to sickle) and extrinsic factors (eg, the capacity of the reticuloendothelial system to remove defective RBCs). Fetal hemoglobin (HbF) is heterogeneously distributed among sickle RBCs; F cells contain 20% to 25% HbF, whereas the remainder have no detectable HbF (non-F cells). Autologous sickle RBCs were labeled with biotin and reinfused to determine overall survival, non–F- and F-cell survival, and time-dependent changes in HbF content (%HbF) for the surviving F cells. A total of 10 patients were enrolled, including 2 who were studied before and after the percentage of F cells was increased by treatment with hydroxyurea. As expected, F cells survived longer in all subjects. Non–F-cell survival correlated inversely with the percentage of F cells, with the time for 30% cell survival ranging from 6 days in patients with more than 88% F cells to 16 days in patients with less than 16% F cells. As the biotin-labeled RBCs aged in the circulation, the HbF content of the surviving F-cell population increased by 0.28%/d ± 0.21%/d, indicating that within the F-cell population those with higher HbF content survived longer. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. M. Cohen, R. S. Franco, P. K. Khera, E. P. Smith, C. J. Lindsell, P. J. Ciraolo, M. B. Palascak, and C. H. Joiner Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c Blood, November 15, 2008; 112(10): 4284 - 4291. [Abstract] [Full Text] [PDF] O. S. Platt Hydroxyurea for the Treatment of Sickle Cell Anemia N. Engl. J. Med., March 27, 2008; 358(13): 1362 - 1369. [Full Text] [PDF]

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