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 Blood, 1 August 2006, Vol. 108, No. 3, pp. 983-985.
Prepublished online as a Blood First Edition Paper on April 20, 2006; DOI 10.1182/blood-2005-09-3824.

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IMMUNOBIOLOGY
Brief report

Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma

Marko Pesu, Linda Muul, Yuka Kanno, and John J. O'Shea

From the Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD.

Interleukin 12 (IL-12) is a major inducer of interferon gamma (IFN-{gamma}) and the principal mediator of T helper 1 (Th1) differentiation. To identify IL-12–regulated genes, which might contribute to Th1 differentiation and IFNG regulation, we employed microarray analysis. Surprisingly, a ubiquitously expressed proprotein convertase (PC), furin, was one of the most consistently IL-12–induced genes in T cells, and among PCs was the only one regulated by this cytokine. Furin was preferentially expressed in differentiated Th1 cells in a Stat4-dependent manner. Expression of furin enhanced IFN-{gamma} secretion, whereas inhibition of furin interfered with IFN-{gamma} production. Thus, we conclude that IL-12 induction of furin might represent a new aspect of IFN-{gamma} regulation and control of Th1 differentiation.


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