Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 15 August 2006, Vol. 108, No. 4, pp. 1189-1197.
Prepublished online as a Blood First Edition Paper on April 20, 2006; DOI 10.1182/blood-2006-01-007187.


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Figure
Right arrow All Versions of this Article:
blood-2006-01-007187v1
108/4/1189    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tang, H.
Right arrow Articles by Cao, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tang, H.
Right arrow Articles by Cao, X.
Related Collections
Right arrow Hematopoiesis and Stem Cells
Right arrow Hemostasis, Thrombosis, and Vascular Biology
Right arrow Stem Cells in Hematology
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

HEMATOPOIESIS

Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10

Hua Tang, Zhenhong Guo, Minghui Zhang, Jianli Wang, Guoyou Chen, and Xuetao Cao

From the Institute of Immunology, Zhejiang University, Hangzhou, PR China; and the Institute of Immunology, Second Military Medical University, Shanghai, PR China.

Regulatory dendritic cells (DCs) have been reported recently, but their origin is poorly understood. Our previous study demonstrated that splenic stroma can drive mature DCs to proliferate and differentiate into regulatory DCs, and their natural counterpart with similar regulatory function in normal spleens has been identified. Considering that the spleen microenvironment supports hematopoiesis and that hematopoietic stem cells (HSCs) are found in spleens of adult mice, we wondered whether splenic microenvironment could differentiate HSCs into regulatory DCs. In this report, we demonstrate that endothelial splenic stroma induce HSCs to differentiate into a distinct regulatory DC subset with high expression of CD11b but low expression of Ia. CD11bhiIalo DCs secreting high levels of TGF-beta, IL-10, and NO can suppress T-cell proliferation both in vitro and in vivo. Furthermore, CD11bhiIalo DCs have the ability to potently suppress allo-DTH in vivo, indicating their preventive or therapeutic perspectives for some immunologic disorders. The inhibitory function of CD11bhiIalo DCs is mediated through NO but not through induction of regulatory T (Treg) cells or T-cell anergy. IL-10, which is secreted by endothelial splenic stroma, plays a critical role in the differentiation of the regulatory CD11bhiIalo DCs from HSCs. These results suggest that splenic microenvironment may physiologically induce regulatory DC differentiation in situ.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
BloodHome page
T. Zhang, S. Liu, P. Yang, C. Han, J. Wang, J. Liu, Y. Han, Y. Yu, and X. Cao
Fibronectin maintains survival of mouse natural killer (NK) cells via CD11b/Src/{beta}-catenin pathway
Blood, November 5, 2009; 114(19): 4081 - 4088.
[Abstract] [Full Text] [PDF]


Home page
CVIHome page
S. Takenaka, S. McCormick, E. Safroneeva, Z. Xing, and J. Gauldie
Influence of the Tissue Microenvironment on Toll-Like Receptor Expression by CD11c+ Antigen-Presenting Cells Isolated from Mucosal Tissues
Clin. Vaccine Immunol., November 1, 2009; 16(11): 1615 - 1623.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Q. Liu, C. Zhang, A. Sun, Y. Zheng, L. Wang, and X. Cao
Tumor-Educated CD11bhighIalow Regulatory Dendritic Cells Suppress T Cell Response through Arginase I
J. Immunol., May 15, 2009; 182(10): 6207 - 6216.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
B. Zhang, R. Liu, D. Shi, X. Liu, Y. Chen, X. Dou, X. Zhu, C. Lu, W. Liang, L. Liao, et al.
Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population
Blood, January 1, 2009; 113(1): 46 - 57.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
S. Xia, Z. Guo, X. Xu, H. Yi, Q. Wang, and X. Cao
Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance
Blood, October 15, 2008; 112(8): 3175 - 3185.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
H. Li, G.-X. Zhang, Y. Chen, H. Xu, D. C. Fitzgerald, Z. Zhao, and A. Rostami
CD11c+CD11b+ Dendritic Cells Play an Important Role in Intravenous Tolerance and the Suppression of Experimental Autoimmune Encephalomyelitis
J. Immunol., August 15, 2008; 181(4): 2483 - 2493.
[Abstract] [Full Text] [PDF]


Home page
Infect. Immun.Home page
C. V. Poncini, C. D. A. Soto, E. Batalla, M. E. Solana, and S. M. Gonzalez Cappa
Trypanosoma cruzi Induces Regulatory Dendritic Cells In Vitro
Infect. Immun., June 1, 2008; 76(6): 2633 - 2641.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
G. Rotta, G. Matteoli, E. Mazzini, P. Nuciforo, M. P. Colombo, and M. Rescigno
Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity
J. Exp. Med., March 17, 2008; 205(3): 657 - 667.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
L. Li, S. Liu, T. Zhang, W. Pan, X. Yang, and X. Cao
Splenic Stromal Microenvironment Negatively Regulates Virus-Activated Plasmacytoid Dendritic Cells through TGF-{beta}
J. Immunol., March 1, 2008; 180(5): 2951 - 2956.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
C. Qian, H. An, Y. Yu, S. Liu, and X. Cao
TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation
Blood, April 15, 2007; 109(8): 3308 - 3315.
[Abstract] [Full Text] [PDF]



 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020