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 Blood, 1 September 2006, Vol. 108, No. 5, pp. 1569-1570.
Prepublished online as a Blood First Edition Paper on April 27, 2006; DOI 10.1182/blood-2006-03-009548.

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Brief report

Fondaparinux is a safe alternative in case of heparin intolerance during pregnancy

Lucia Mazzolai, Patrick Hohlfeld, Francois Spertini, Daniel Hayoz, Marc Schapira, and Michel A. Duchosal

From the services of Vascular Medicine, Obstetrics, Immunology and Allergy, and Hematology, University Hospital of Lausanne (CHUV), Switzerland.

Heparin is the drug of choice for the treatment or the prevention of thromboembolic disease during pregnancy. However, treatment options are limited when heparin cannot be used because of hypersensitivity skin reactions. Despite the recent availability of new anticoagulant agents, data relating to their use during pregnancy are lacking. This report describes the successful management with fondaparinux, during 150 days, of a pregnant patient with protein S deficiency and prior deep vein thrombosis (DVT) who developed heparin and danaparoid hypersensitivity.


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