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Blood, 15 September 2006, Vol. 108, No. 6, pp. 1857-1864. Prepublished online as a Blood First Edition Paper on May 30, 2006; DOI 10.1182/blood-2005-10-007658. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2005-10-007658v1 108/6/1857    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bungartz, G. Articles by Brakebusch, C. Search for Related Content PubMed PubMed Citation Articles by Bungartz, G. Articles by Brakebusch, C. Related Collections Hematopoiesis and Stem Cells Cell Adhesion and Motility Stem Cells in Hematology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Adult murine hematopoiesis can proceed without 1 and 7 integrins Gerd Bungartz, Sebastian Stiller, Martina Bauer, Werner Müller, Angela Schippers, Norbert Wagner, Reinhard Fässler, and Cord Brakebusch From the Max Planck Institute of Biochemistry, Department of Molecular Medicine, and the Heisenberg Group "Regulation of Cytoskeletal Organization," Martinsried, Germany; the German Research Center for Biotechnology (GBF), Department of Experimental Immunology, Braunschweig, Germany; and the Department of Pediatrics, City Hospital of Dortmund, Germany. The function of 41 and 47 integrins in hematopoiesis is controversial. While some experimental evidence suggests a crucial role for these integrins in retention and expansion of progenitor cells and lymphopoiesis, others report a less important role in hematopoiesis. Using mice with a deletion of the 1 and the 7 integrin genes restricted to the hematopoietic system we show here that 41 and 47 integrins are not essential for differentiation of lymphocytes or myelocytes. However, 17 mutant mice displayed a transient increase of colony-forming unit (CFU-C) progenitors in the bone marrow and, after phenylhydrazine-induced anemia, a decreased number of splenic erythroid colony-forming units in culture (CFUe's). Array gene expression analysis of CD4+CD8+ double-positive (DP) and CD4–CD8– double-negative (DN) thymocytes and CD19+ and CD4+ splenocytes did not provide any evidence for a compensatory mechanism explaining the mild phenotype. These data show that 41 and 47 are not required for blood cell differentiation, although in their absence alterations in numbers and distribution of progenitor cells were observed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+4f/f mice are hematopoietic cell autonomous Gregory V. Priestley, Tatiana Ulyanova, and Thalia Papayannopoulou Blood 2007 109: 109-111. [Abstract] [Full Text] [PDF] This article has been cited by other articles: C. Coisne, W. Mao, and B. Engelhardt Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-Brain Barrier In Vivo in an Animal Model of Multiple Sclerosis J. Immunol., May 15, 2009; 182(10): 5909 - 5913. [Abstract] [Full Text] [PDF] M. Bauer, C. Brakebusch, C. Coisne, M. Sixt, H. Wekerle, B. Engelhardt, and R. Fassler {beta}1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity PNAS, February 10, 2009; 106(6): 1920 - 1925. [Abstract] [Full Text] [PDF] T. Ulyanova, G. V. Priestley, Y. Jiang, S. Padilla, and T. Papayannopoulou b1 Integrin Deficiency in Both Erythroid Cells and Their Microenvironment Does Not Affect Basal Erythropoiesis but Critically Impairs Survival and Erythroid Response to Phenylhydrazine-Induced Stress in Adult Mice Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 3567 - 3567. [Abstract] A. M. O'Reilly, H.-H. Lee, and M. A. Simon Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary J. Cell Biol., August 25, 2008; 182(4): 801 - 815. [Abstract] [Full Text] [PDF] B. Metzler, B. Haubner, E. Conci, J. Voelkl, J. Jehle, M. Bauer, D. Wolf, O. Pachinger, and Q. Xu Myocardial ischaemia-reperfusion injury in haematopoietic cell-restricted {beta}1 integrin knockout mice Exp Physiol, July 1, 2008; 93(7): 825 - 833. [Abstract] [Full Text] [PDF] H. Qian, E. Georges-Labouesse, A. Nystrom, A. Domogatskaya, K. Tryggvason, S. E. W. Jacobsen, and M. Ekblom Distinct roles of integrins {alpha}6 and {alpha}4 in homing of fetal liver hematopoietic stem and progenitor cells Blood, October 1, 2007; 110(7): 2399 - 2407. [Abstract] [Full Text] [PDF]

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