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Blood, 15 September 2006, Vol. 108, No. 6, pp. 2124-2126. Prepublished online as a Blood First Edition Paper on May 25, 2006; DOI 10.1182/blood-2006-03-009712. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-03-009712v1 108/6/2124    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cohen, J. M. Articles by Veys, P. Search for Related Content PubMed PubMed Citation Articles by Cohen, J. M. Articles by Veys, P. Related Collections Immunobiology Transplantation Immunotherapy Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Serial transplantation of mismatched donor hematopoietic cells between HLA-identical sibling pairs with congenital immunodeficiency: in vivo tolerance permits rapid immune reconstitution following T-replete transplantation without GVHD in the secondary recipient Jonathan M. Cohen, Valerie Rogers, H. Bobby Gaspar, Alison Jones, E. Graham Davies, Kanchan Rao, Daniel J. McCloskey, Kimberley Gilmour, Robert Wynn, Persis J. Amrolia, and Paul Veys From the Departments of Bone Marrow Transplantation and Clinical Immunology, Great Ormond Street Hospital National Health Service (NHS) Trust, London, United Kingdom; the Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom; the Clinical Transplantation Laboratory, Barts and The London NHS Trust, London, United Kingdom; and the Department of Haematology and Bone Marrow Transplantation, Manchester Royal Infirmary, Manchester, United Kingdom. We report serial transplantation procedures in 2 sets of brothers with X-linked primary immunodeficiency. The first boy in each family received a T-cell–depleted transplant from a mismatched donor. The recipients then acted as donors for T-replete transplantation of the "tolerized" graft into their HLA-identical brothers with the same disorder. Immune reconstitution was noted to occur at a significantly faster rate in the secondary recipients, and without the occurrence of graft-versus-host disease (GVHD), despite the presence of donor cells mismatched for 1 to 3 HLA antigens. This serial transplantation technique allows the primary recipient of HLA-mismatched donor cells to act as a functionally "HLA-matched" donor for subsequent affected siblings, and should be considered as a therapeutic option in families with congenital disorders. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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