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Blood, 15 October 2006, Vol. 108, No. 8, pp. 2608-2615. Prepublished online as a Blood First Edition Paper on June 29, 2006; DOI 10.1182/blood-2005-12-019919. This Article Full Text Full Text (PDF) Supplemental Figures and Videos All Versions of this Article: blood-2005-12-019919v1 108/8/2608    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fons, P. Articles by Le Bouteiller, P. Search for Related Content PubMed PubMed Citation Articles by Fons, P. Articles by Le Bouteiller, P. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Apoptosis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells Pierre Fons, Sophie Chabot, Judith E. Cartwright, Francoise Lenfant, Fatima L'Faqihi, Jerome Giustiniani, Jean-Pascal Herault, Genevieve Gueguen, Françoise Bono, Pierre Savi, Maryse Aguerre-Girr, Sylvie Fournel, François Malecaze, Armand Bensussan, Jean Plouët, and Philippe Le Bouteiller From the Institut de Pharmacologie et Biologie Structurale, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5089, Toulouse, France; Sanofi-Aventis Research, Toulouse, France; Institut National de la Santé et de la Recherche Médicale Unité 563/Université Paul Sabatier, Hôpital Purpan, Toulouse, France; Department of Basic Medical Sciences, St. George's, University of London, United Kingdom; Institut National de la Santé et de la Recherche Médicale Unité 659, Faculté de Médecine de Créteil, Créteil, France; and Institut National de la Santé et de la Recherche Médicale Unité 689, Institute des Vaisseaux et du Sang, Paris, France. HLA-G is a major histocompatibility complex class Ib molecule whose constitutive tissue distribution is restricted mainly to trophoblast cells at the maternal-fetal interface during pregnancy. In this study, we demonstrated the ability of the soluble HLA-G1 (sHLA-G1) isoform to inhibit fibroblast growth factor-2 (FGF2)-induced capillary-like tubule formation. Using a rabbit corneal neovascularization model, we further showed that sHLA-G1 inhibits FGF2-induced angiogenesis in vivo. We also demonstrated that sHLA-G1 induces endothelial cell apoptosis through binding to BY55/CD160, a glycosylphosphatidylinositolanchored receptor expressed by endothelial cells. Furthermore, we showed that the specific CL1-R2 anti-CD160 monoclonal antibody mimics sHLA-G1-mediated inhibition of endothelial cell tube formation and induction of apoptosis. Thus, the engagement of CD160 in endothelial cells may be essential for the inhibition of angiogenesis. sHLA-G1/CD160-mediated antiangiogenic property may participate in the vascular remodeling of maternal spiral arteries during pregnancy, and, given that we found that CD160 is strongly expressed in the vasculature of a murine tumor, it offers an attractive therapeutic target for preventing pathologic neovascularization. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. McCormick, G. S. J. Whitley, P. Le Bouteiller, and J. E. Cartwright Soluble HLA-G regulates motility and invasion of the trophoblast-derived cell line SGHPL-4 Hum. Reprod., June 1, 2009; 24(6): 1339 - 1345. [Abstract] [Full Text] [PDF] G. C. Douglas, C. A. VandeVoort, P. Kumar, T.-C. Chang, and T. G. Golos Trophoblast Stem Cells: Models for Investigating Trophectoderm Differentiation and Placental Development Endocr. 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