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Blood, 15 October 2006, Vol. 108, No. 8, pp. 2687-2694. Prepublished online as a Blood First Edition Paper on July 6, 2006; DOI 10.1182/blood-2005-12-017319. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2005-12-017319v1 108/8/2687    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chang, S. K. Articles by Jelinek, D. F. Search for Related Content PubMed PubMed Citation Articles by Chang, S. K. Articles by Jelinek, D. F. Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY A role for BLyS in the activation of innate immune cells Sook Kyung Chang, Bonnie K. Arendt, Jaime R. Darce, Xiaosheng Wu, and Diane F. Jelinek From the Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN. B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily. Although BLyS costimulates adaptive immune cells, the ability of BLyS to stimulate innate immune cells has not been described. Here, we show that BLyS strongly induces human monocyte survival, and activation as measured by proinflammatory cytokine secretion and up-regulation of costimulatory molecule expression. In addition, monocytes cultured with BLyS differentiated into macrophage-like cells. Regarding BLyS receptor(s) expression, freshly isolated monocytes bound low levels of exogenous BLyS and expressed primarily intracellular TACI, and cell surface TACI levels increased following monocyte activation. Of interest, bone marrow monocytes from some multiple myeloma patients expressed significant levels of cell surface TACI at isolation. Our findings indicate that BLyS plays a role in activating innate immune cells. Moreover, this study may explain more clearly why high BLyS production is often correlated with certain inflammatory autoimmune diseases and B-lymphocyte malignancies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D T La, C E Collins, H-T Yang, T-S Migone, and W Stohl B lymphocyte stimulator expression in patients with rheumatoid arthritis treated with tumour necrosis factor {alpha} antagonists: differential effects between good and poor clinical responders Ann Rheum Dis, August 1, 2008; 67(8): 1132 - 1138. [Abstract] [Full Text] [PDF] S. K. Chang, S. A. Mihalcik, and D. F. Jelinek B Lymphocyte Stimulator Regulates Adaptive Immune Responses by Directly Promoting Dendritic Cell Maturation J. Immunol., June 1, 2008; 180(11): 7394 - 7403. [Abstract] [Full Text] [PDF] D. L. Langat, D. A. Wheaton, J. S. Platt, T. Sifers, and J. S. Hunt Signaling Pathways for B Cell-Activating Factor (BAFF) and a Proliferation-Inducing Ligand (APRIL) in Human Placenta Am. J. Pathol., May 1, 2008; 172(5): 1303 - 1311. [Abstract] [Full Text] [PDF] L. Schiffer, R. Bethunaickan, M. Ramanujam, W. Huang, M. Schiffer, H. Tao, M. M. Madaio, E. P. Bottinger, and A. Davidson Activated Renal Macrophages Are Markers of Disease Onset and Disease Remission in Lupus Nephritis J. Immunol., February 1, 2008; 180(3): 1938 - 1947. [Abstract] [Full Text] [PDF] J. R. Darce, B. K. Arendt, S. K. Chang, and D. F. Jelinek Divergent Effects of BAFF on Human Memory B Cell Differentiation into Ig-Secreting Cells J. Immunol., May 1, 2007; 178(9): 5612 - 5622. [Abstract] [Full Text] [PDF]

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