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 Blood, 1 November 2006, Vol. 108, No. 9, pp. 2893-2896.
Prepublished online as a Blood First Edition Paper on July 13, 2006; DOI 10.1182/blood-2006-04-016600.

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PERSPECTIVES

Hematopoietic origin of fibroblasts/myofibroblasts: its pathophysiologic implications

Makio Ogawa, Amanda C. LaRue, and Christopher J. Drake

From the Department of Veterans Affairs Medical Center, Charleston, SC; and Division of Experimental Hematology, Department of Medicine, and Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC.

Abstract

Tissue fibroblasts/myofibroblasts play a key role in growth factor secretion, matrix deposition, and matrix degradation, and therefore are important in many pathologic processes. Regarding the origin of tissue fibroblasts/myofibroblasts, a number of recent in vivo transplantation studies have suggested the bone marrow as the source of fibroblasts/myofibroblasts in liver, intestine, skin, and lung. Because bone marrow cells are thought to contain 2 types of stem cells (ie, hematopoietic stem cells [HSCs] and mesenchymal stem cells), it is important to determine which type of stem cells is the source of fibroblasts/myofibroblasts. To address this issue, we have carried out a series of studies of tissue reconstitution by single HSCs. By transplanting clones derived from single HSCs expressing transgenic enhanced green fluorescent protein, we found that fibroblasts/myofibroblasts in many organs and tissues are derived from HSCs. This brief note summarizes these findings and discusses clinical and experimental perspectives generated by this newly identified differentiation pathway of HSCs.


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