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Blood, 1 November 2006, Vol. 108, No. 9, pp. 3068-3071. Prepublished online as a Blood First Edition Paper on July 18, 2006; DOI 10.1182/blood-2006-01-012369. This Article Full Text Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2006-01-012369v1 108/9/3068    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Poliseno, L. Articles by Rainaldi, G. Search for Related Content PubMed PubMed Citation Articles by Poliseno, L. Articles by Rainaldi, G. Related Collections Free Research Articles Gene Therapy Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report MicroRNAs modulate the angiogenic properties of HUVECs Laura Poliseno, Andrea Tuccoli, Laura Mariani, Monica Evangelista, Lorenzo Citti, Keith Woods, Alberto Mercatanti, Scott Hammond, and Giuseppe Rainaldi From the Laboratory of Gene and Molecular Therapy, Institute of Clinical Physiology, CNR, Pisa, Italy; and the Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC. MicroRNAs (miRNAs) have recently come into focus as key posttranscriptional modulators of gene expression. In this work, we addressed whether in vitro angiogenesis is an miRNA-regulated process. We performed large-scale analysis of miRNA expression in human umbilical vein endothelial cells (HUVECs) and found that 15 highly expressed miRNAs have the receptors of angiogenic factors as putative targets. In particular, we demonstrated that miR-221 and miR-222 affect c-Kit expression and, as a consequence, the angiogenic properties of its ligand stem cell factor. Interaction between miR-222 and c-Kit is likely to be part of a complex circuit that controls the ability of endothelial cells to form new capillaries. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: MicroRNAs control angiogenesis Cesare Peschle Blood 2006 108: 2887-2888. [Full Text] [PDF] This article has been cited by other articles: C. Urbich, A. Kuehbacher, and S. Dimmeler Role of microRNAs in vascular diseases, inflammation, and angiogenesis Cardiovasc Res, July 1, 2008; (2008) cvn156v2. [Abstract] [Full Text] [PDF] C. Zhang MicroRNomics: a newly emerging approach for disease biology Physiol Genomics, April 21, 2008; 33(2): 139 - 147. [Abstract] [Full Text] [PDF] F. Felicetti, M. C. Errico, L. Bottero, P. Segnalini, A. Stoppacciaro, M. Biffoni, N. Felli, G. Mattia, M. Petrini, M. P. Colombo, et al. The Promyelocytic Leukemia Zinc Finger-MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms Cancer Res., April 15, 2008; 68(8): 2745 - 2754. [Abstract] [Full Text] [PDF] A. J. O'Hara, W. Vahrson, and D. P. Dittmer Gene alteration and precursor and mature microRNA transcription changes contribute to the miRNA signature of primary effusion lymphoma Blood, February 15, 2008; 111(4): 2347 - 2353. [Abstract] [Full Text] [PDF] T. A. Harris, M. Yamakuchi, M. Ferlito, J. T. Mendell, and C. J. Lowenstein MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1 PNAS, February 5, 2008; 105(5): 1516 - 1521. [Abstract] [Full Text] [PDF] Y. Chen and D. 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Dimmeler Role of Dicer and Drosha for Endothelial MicroRNA Expression and Angiogenesis Circ. Res., July 6, 2007; 101(1): 59 - 68. [Abstract] [Full Text] [PDF] R. Ji, Y. Cheng, J. Yue, J. Yang, X. Liu, H. Chen, D. B. Dean, and C. Zhang MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation Circ. Res., June 8, 2007; 100(11): 1579 - 1588. [Abstract] [Full Text] [PDF] M. Bloomston, W. L. Frankel, F. Petrocca, S. Volinia, H. Alder, J. P. Hagan, C.-G. Liu, D. Bhatt, C. Taccioli, and C. M. Croce MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis JAMA, May 2, 2007; 297(17): 1901 - 1908. [Abstract] [Full Text] [PDF] C. Blenkiron and E. A. Miska miRNAs in cancer: approaches, aetiology, diagnostics and therapy Hum. Mol. Genet., April 15, 2007; 16(R1): R106 - R113. [Abstract] [Full Text] [PDF]

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