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Blood, 1 January 2007, Vol. 109, No. 1, pp. 359-361. Prepublished online as a Blood First Edition Paper on September 12, 2006; DOI 10.1182/blood-2006-05-023762. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2006-05-023762v1 109/1/359    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Alyanakian, M.-A. Articles by Beaumont, C. Search for Related Content PubMed PubMed Citation Articles by Alyanakian, M.-A. Articles by Beaumont, C. Related Collections Red Cells Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Brief report Monoclonal immunoglobulin with antitransferrin activity: a rare cause of hypersideremia with increased transferrin saturation Marie-Alexandra Alyanakian1, Youri Taes2, Mimouna Bensaïd1, Berta Segovia1, Pierre Aucouturier1, Jean-Didier Rain3, Joris Delanghe2, Bruno Varet4, and Carole Beaumont5, 1 Université Paris 5 René Descartes; Assistance Publique–Hôpitaux de Paris (AP-HP), Laboratoire d'Immunologie, Hôpital Necker, Paris, France; 2 Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium; 3 AP-HP, Service de Médicine Nucléaire, Hôpital St Louis, Paris, France; 4 Université Paris 5 René Descartes; AP-HP, Service d'Hématologie adultes, Hôpital Necker, Paris, France; and 5 Institut National de la Santé et de la Recherche Médicale (INSERM), U773, Centre de Recherche Biomédicale, Paris, France; Université Paris 7 Denis Diderot, Paris, France Two unusual but similar cases of very high serum iron, extremely high transferrin concentrations (5.4 to 6.5 g/L), and increased transferrin saturation are reported. No anemia or microcytosis was observed. The ferritin concentration remained within the normal range, and no iron overload was observed. In one case, the in vivo half-life of 59Fe-labeled transferrin was shown to be prolonged (206 minutes versus 75 minutes for controls). In both patients, a monoclonal IgG was observed in the serum. The association between serum transferrin and monoclonal IgG was demonstrated by Western blot analysis and affinity chromatography. We suggest that the transferrin bound to the monoclonal IgG molecule has a prolonged half-life in the circulation, leading to high transferrin concentrations, and that the increased serum iron values prevent the onset of anemia. The antitransferrin activity of monoclonal antibody should be added to the list of situations accounting for elevated serum iron with elevated transferrin saturation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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