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Blood, 15 May 2007, Vol. 109, No. 10, pp. 4586-4588.
Prepublished online as a Blood First Edition Paper on January 18, 2007; DOI 10.1182/blood-2006-10-054924.
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TRANSPLANTATION
Brief Report
Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation
Philippe Armand1,
Haesook T. Kim2,
Corey S. Cutler1,
Vincent T. Ho1,
John Koreth1,
Edwin P. Alyea1,
Robert J. Soiffer1, and
Joseph H. Antin1
1 Department of Medical Oncology and
2 Department of Biostatistics, Dana-Farber Cancer Institute, Boston, MA
Iron overload could be a significant contributor to treatment-related mortality (TRM) for patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT). We studied 590 patients who underwent myeloablative allogeneic HSCT at our institution, and on whom a pretransplantation serum ferritin was available. An elevated pretransplantation serum ferritin level was strongly associated with lower overall and disease-free survival. Subgroup multivariable analyses demonstrated that this association was restricted to patients with acute leukemia or myelodysplastic syndrome (MDS); in the latter group, the inferior survival was attributable to a significant increase in TRM. There was also a trend toward an increased risk of veno-occlusive disease in patients with high ferritin. Our results argue that iron overload plays an important role in transplantation outcome for patients with acute leukemia or MDS, as it does in thalassemia. They also suggest future prospective trials to examine the potential benefit of chelation therapy in this setting.
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