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Blood, 1 June 2007, Vol. 109, No. 11, pp. 4825-4931. Prepublished online as a Blood First Edition Paper on February 22, 2007; DOI 10.1182/blood-2006-08-043810. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-08-043810v1 109/11/4825    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Welner, R. S. Articles by Kincade, P. W. Search for Related Content PubMed PubMed Citation Articles by Welner, R. S. Articles by Kincade, P. W. Related Collections Hematopoiesis and Stem Cells Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors Robert S. Welner1,2, Rosana Pelayo1, Karla P. Garrett1, Xinrong Chen1, S. Scott Perry1, Xiao-Hong Sun1, Barbara L. Kee3, and Paul W. Kincade1 1 Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK; 2 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 3 Department of Pathology, University of Chicago, Chicago, IL Interferon-producing killer dendritic cells (IKDCs) have only recently been described and they share some properties with plasmacytoid dendritic cells (pDCs). We now show that they can arise from some of the same progenitors. However, IKDCs expressed little or no RAG-1, Spi-B, or TLR9, but responded to the TLR9 agonist CpG ODN by production of IFN. The RAG-1–pDC2 subset was more similar to IKDCs than RAG-1+ pDC1s with respect to IFN production. The Id-2 transcriptional inhibitor was essential for production of IKDCs and natural killer (NK) cells, but not pDCs. IKDCs developed from lymphoid progenitors in culture but, unlike pDCs, were not affected by Notch receptor ligation. While IKDCs could be made from estrogen-sensitive progenitors, they may have a slow turnover because their numbers did not rapidly decline in hormone-treated mice. Four categories of progenitors were compared for IKDC-producing ability in transplantation assays. Of these, Lin–Sca-1+c-KitHiThy1.1–L-selectin+ lymphoid progenitors (LSPs) were the best source. While NK cells resemble IKDCs in several respects, they develop from different progenitors. These observations suggest that IKDCs may arise from a unique differentiation pathway, and one that diverges early from those responsible for NK cells, pDCs, and T and B cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Ullrich, M. Bonmort, G. Mignot, B. Jacobs, D. Bosisio, S. Sozzani, A. Jalil, F. Louache, E. Bulanova, F. Geissman, et al. Trans-Presentation of IL-15 Dictates IFN-Producing Killer Dendritic Cells Effector Functions J. Immunol., June 15, 2008; 180(12): 7887 - 7897. [Abstract] [Full Text] [PDF] M. C. Siracusa, M. G. Overstreet, F. Housseau, A. L. Scott, and S. L. Klein 17{beta}-Estradiol Alters the Activity of Conventional and IFN-Producing Killer Dendritic Cells J. Immunol., February 1, 2008; 180(3): 1423 - 1431. [Abstract] [Full Text] [PDF] E. Carreras, S. Turner, V. Paharkova-Vatchkova, A. Mao, C. Dascher, and S. Kovats Estradiol Acts Directly on Bone Marrow Myeloid Progenitors to Differentially Regulate GM-CSF or Flt3 Ligand-Mediated Dendritic Cell Differentiation J. Immunol., January 15, 2008; 180(2): 727 - 738. [Abstract] [Full Text] [PDF] A. L. Blasius, W. Barchet, M. Cella, and M. Colonna Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells J. Exp. Med., October 29, 2007; 204(11): 2561 - 2568. [Abstract] [Full Text] [PDF] I. Caminschi, F. Ahmet, K. Heger, J. Brady, S. L. Nutt, D. Vremec, S. Pietersz, M. H. Lahoud, L. Schofield, D. S. Hansen, et al. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells J. Exp. Med., October 29, 2007; 204(11): 2579 - 2590. [Abstract] [Full Text] [PDF] C. A.J. Vosshenrich, S. Lesjean-Pottier, M. Hasan, O. Richard-Le Goff, E. Corcuff, O. Mandelboim, and J. P. Di Santo CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells J. Exp. Med., October 29, 2007; 204(11): 2569 - 2578. [Abstract] [Full Text] [PDF] U. I. Chaudhry, G. Plitas, B. M. Burt, T. P. Kingham, J. R. Raab, and R. P. DeMatteo NK Dendritic Cells Expanded in IL-15 Exhibit Antitumor Responses In Vivo J. Immunol., October 1, 2007; 179(7): 4654 - 4660. [Abstract] [Full Text] [PDF]

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