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Blood, 15 January 2007, Vol. 109, No. 2, pp. 478-485. Prepublished online as a Blood First Edition Paper on September 19, 2006; DOI 10.1182/blood-2006-01-021253. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2006-01-021253v1 109/2/478    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Murase, T. Articles by Nakamura, S. Search for Related Content PubMed PubMed Citation Articles by Murase, T. Articles by Nakamura, S. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5 Takuhei Murase1,, Motoko Yamaguchi2, Ritsuro Suzuki3, Masataka Okamoto4, Yumiko Sato5, Jun-ichi Tamaru6, Masaru Kojima7, Ikuo Miura8, Naoyoshi Mori9, Tadashi Yoshino5, and Shigeo Nakamura9 1 Department of Internal Medicine, Nishio Municipal Hospital, Nishio, Japan; 2 Department of Hematology, Mie University Graduate School of Medicine, Tsu, Japan; 3 Department of Hematopoietic Stem Cell Transplantation Data Management, Nagoya University School of Medicine, Nagoya, Japan; 4 Division of Hematology and Medical Oncology, Department of Medicine, Fujita Health University School of Medicine, Toyoake, Japan; 5 Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan; 6 Department of Pathology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan; 7 Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ota, Japan; 8 Department of Hematology and Oncology, St Marianne University School of Medicine, Kawasaki, Japan; 9 Department of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan Intravascular large B-cell lymphoma (IVLBCL) is pathologically distinct with a broad clinical spectrum and immunophenotypic heterogeneity. A series of 96 patients with IVLBCL (median age, 67 years; range, 41-85 years; 50 men) was reviewed. Anemia/thrombocytopenia (84%), hepatosplenomegaly (77%), B symptoms (76%), bone marrow involvement (75%), and hemophagocytosis (61%) were frequently observed. The International Prognostic Index score was high or high-intermediate in 92%. For 62 patients receiving anthracycline-based chemotherapies, median survival was 13 months. CD5, CD10, Bcl-6, MUM1, and Bcl-2 were positive in 38%, 13%, 26%, 95%, and 91% of tumors, respectively. All 59 CD10– IVLBCL cases examined were nongerminal center B-cell type because they lacked the Bcl-6+MUM1– immunophenotype. CD5 positivity was associated with a higher prevalence of marrow/blood involvement and thrombocytopenia and a lower frequency of neurologic abnormalities among patients with CD10–IVLBCL. Compared with 97 cases of de novo CD5+CD10–diffuse LBCL, 31 cases of CD5+CD10–IVLBCL exhibited higher frequencies of poor prognostic parameters, except age. Multivariate analysis in IVLBCL revealed that a lack of anthracycline-based chemotherapies (P < .001, hazard ratio [HR]: 9.256), age older than 60 years (P = .012, HR: 2.459), and thrombocytopenia less than 100 x 109/L (P = .012, HR: 2.427) were independently unfavorable prognostic factors; CD5 positivity was not. Beyond immunophenotypic diversity, IVLBCL constitutes a unique group with aggressive behavior. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. H. Hochberg, F. J. Rodriguez, J.L.D. Atkinson, E. G. Shaw, B. M. Keegan, and O. H. Kantarci A 54-year-old woman with progressive gait disturbance and MRI abnormalities Neurology, August 11, 2009; 73(6): 466 - 474. [Full Text] [PDF] A. M. Maeshima, H. Taniguchi, J. Nomoto, D. Maruyama, S.-W. Kim, T. Watanabe, Y. Kobayashi, K. Tobinai, and Y. Matsuno Secondary CD5+ Diffuse Large B-Cell Lymphoma Not Associated With Transformation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Richter Syndrome) Am J Clin Pathol, March 1, 2009; 131(3): 339 - 346. [Abstract] [Full Text] [PDF] M. Yamaguchi, N. Nakamura, R. Suzuki, Y. Kagami, M. Okamoto, R. Ichinohasama, T. Yoshino, J. Suzumiya, T. Murase, I. Miura, et al. De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients Haematologica, August 1, 2008; 93(8): 1195 - 1202. [Abstract] [Full Text] [PDF] K. Shimada, K. Matsue, K. Yamamoto, T. Murase, N. Ichikawa, M. Okamoto, N. Niitsu, H. Kosugi, N. Tsukamoto, H. Miwa, et al. Retrospective Analysis of Intravascular Large B-Cell Lymphoma Treated With Rituximab-Containing Chemotherapy As Reported by the IVL Study Group in Japan J. Clin. Oncol., July 1, 2008; 26(19): 3189 - 3195. [Abstract] [Full Text] [PDF] M Roshal, B G Till, J R Fromm, and S Cherian Intravascular large B cell lymphoma presenting in a liver explant J. Clin. Pathol., July 1, 2008; 61(7): 877 - 878. [Full Text] [PDF] W. Ishii, S. Ito, Y. Kondo, H. Tsuboi, M. Mamura, D. Goto, I. Matsumoto, A. Tsutsumi, T. Sumida, Y. Okoshi, et al. Intravascular Large B-Cell Lymphoma With Acute Abdomen As a Presenting Symptom in a Patient With Systemic Lupus Erythematosus J. Clin. Oncol., March 20, 2008; 26(9): 1553 - 1555. [Full Text] [PDF] N. Asada, J. Odawara, S.-i. Kimura, T. Aoki, M. Yamakura, M. Takeuchi, R. Seki, A. Tanaka, and K. Matsue Use of Random Skin Biopsy for Diagnosis of Intravascular Large B-Cell Lymphoma Mayo Clin. Proc., December 1, 2007; 82(12): 1525 - 1527. [Abstract] [Full Text] [PDF] G. S. Meyer, C. A. Hales, P. C. Amrein, A. Sharma, and R. L. Kradin Case 26-2007 -- A 61-Year-Old Man with Recurrent Fevers N. Engl. J. Med., August 23, 2007; 357(8): 807 - 816. [Full Text] [PDF] M. Ponzoni, A. J.M. Ferreri, E. Campo, F. Facchetti, L. Mazzucchelli, T. Yoshino, T. Murase, S. A. Pileri, C. Doglioni, E. Zucca, et al. Definition, Diagnosis, and Management of Intravascular Large B-Cell Lymphoma: Proposals and Perspectives From an International Consensus Meeting J. Clin. Oncol., July 20, 2007; 25(21): 3168 - 3173. [Abstract] [Full Text] [PDF] S. Nakamura, T. Murase, and T. Kinoshita Intravascular large B-cell lymphoma: the heterogeneous clinical manifestations of its classical and hemophagocytosis-related forms Haematologica, April 1, 2007; 92(4): 434 - 436. [Full Text] [PDF] A. J.M. Ferreri, G. P. Dognini, E. Campo, R. Willemze, J. F. Seymour, O. Bairey, M. Martelli, A. De Renzo, C. Doglioni, C. Montalban, et al. Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions Haematologica, April 1, 2007; 92(4): 486 - 492. [Abstract] [Full Text] [PDF]

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