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Blood, 15 January 2007, Vol. 109, No. 2, pp. 613-615. Prepublished online as a Blood First Edition Paper on September 21, 2006; DOI 10.1182/blood-2006-05-026401. This Article Full Text Full Text (PDF) Supplemental Table, Figures, and Video All Versions of this Article: blood-2006-05-026401v1 109/2/613    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yano, K. Articles by Aird, W. C. Search for Related Content PubMed PubMed Citation Articles by Yano, K. Articles by Aird, W. C. Related Collections Hemostasis, Thrombosis, and Vascular Biology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium Kiichiro Yano1, Daniel Gale1, Steffen Massberg2, Pavan K. Cheruvu1, Rita Monahan-Earley3, Ellen S. Morgan3, David Haig4, Ulrich H. von Andrian2, Ann M. Dvorak1,3, and William C. Aird1,5, 1 Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA; 2 Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA; 3 Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA; 4 Department of Organismic and Evolutionary Biology, Harvard University, Boston, MA; 5 Mount Desert Island Biological Laboratory, Salisbury Cove, ME Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have already been present in this ancestral vertebrate. The goal of this study was to determine whether the hagfish endothelium displays phenotypic heterogeneity. Electron microscopy of the aorta, dermis, heart, and liver revealed ultrastructural heterogeneity of the endothelium. Immunofluorescent studies demonstrated marked differences in lectin binding between vascular beds. Intravital microscopy of the dermis revealed histamine-induced adhesion of leukocytes in capillaries and postcapillary venules, but no such adhesion in arterioles. Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. F. Alvarez, L. Huang, J. A. King, M. K. ElZarrad, M. C. Yoder, and T. Stevens Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L419 - L430. [Abstract] [Full Text] [PDF] R.-H. Huang, Y. Wang, R. Roth, X. Yu, A. R. Purvis, J. E. Heuser, E. H. Egelman, and J. E. Sadler Assembly of Weibel Palade body-like tubules from N-terminal domains of von Willebrand factor PNAS, January 15, 2008; 105(2): 482 - 487. [Abstract] [Full Text] [PDF] J. Feng, K. Yano, R. Monahan-Earley, E. S. Morgan, A. M. Dvorak, F. W. Sellke, and W. C. Aird Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R894 - R900. [Abstract] [Full Text] [PDF]

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