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Blood, 15 January 2007, Vol. 109, No. 2, pp. 786-791. Prepublished online as a Blood First Edition Paper on August 3, 2006; DOI 10.1182/blood-2006-05-024844. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-024844v1 109/2/786    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Spoo, A. C. Articles by Burger, J. A. Search for Related Content PubMed PubMed Citation Articles by Spoo, A. C. Articles by Burger, J. A. Related Collections Chemokines, Cytokines, and Interleukins Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA CXCR4 is a prognostic marker in acute myelogenous leukemia Anke C. Spoo1, Michael Lübbert1, William G. Wierda2, and Jan A. Burger1,2, 1 Division of Hematology/Oncology, Department of Medicine, Freiburg University Hospital, Germany; 2 Leukemia Department, University of Texas M. D. Anderson Cancer Center, Houston CXCR4 chemokine receptors retain hematopoietic progenitors and leukemia cells within the marrow microenvironment. We prospectively evaluated the prognostic implication of CXCR4 in 90 consecutive patients with acute myelogenous leukemia (AML) by flow cytometry. Patients were divided into groups with low (n = 32), intermediate (n = 26), or high (n = 32) CXCR4 expression, as defined by CXCR4 mean fluorescence intensity ratio thresholds of less than 5, 5 to 10, or more than 10, respectively. We found that low CXCR4 expression on AML cells correlated with a better prognosis, resulting in a longer relapse-free and overall survival of 24.3 ± 2.9 months for low CXCR4-expressing patients, compared with 17.4 ± 3.4 months for intermediate and 12.8 ± 2 months (mean ± SEM) for patients with high expression. In univariate analyses, CXCR4 expression, cytogenetics, white blood cell count, and serum lactate dehydrogenase (LDH) predicted for shorter survival. Multivariate analysis revealed CXCR4 expression and unfavorable cytogenetics as independent prognostic factors. We conclude that CXCR4 expression in AML is an independent prognostic predictor for disease relapse and survival that can rapidly and easily be determined at disease presentation. These findings warrant further investigation into the role of CXCR4 in AML and suggest that CXCR4 should be incorporated into the risk assessment of AML patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. M. Stone Genetically Defined Prognostic Factors and Novel Therapeutics for AML ASCO Educational Book, January 1, 2008; 2008(1): 280 - 284. [Abstract] [Full Text] [PDF] W. Zhang, J.-M. Navenot, N. M. Frilot, N. Fujii, and S. C. Peiper Association of Nucleophosmin Negatively Regulates CXCR4-Mediated G Protein Activation and Chemotaxis Mol. Pharmacol., November 1, 2007; 72(5): 1310 - 1321. [Abstract] [Full Text] [PDF] O. Bruserud, A. Ryningen, A. M. Olsnes, L. Stordrange, A. M. Oyan, K. H. Kalland, and B. T. Gjertsen Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells Haematologica, March 1, 2007; 92(3): 332 - 341. [Abstract] [Full Text] [PDF]

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