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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1051-1060. Prepublished online as a Blood First Edition Paper on September 21, 2006; DOI 10.1182/blood-2006-06-026781. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-06-026781v1 109/3/1051    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Twizere, J.-C. Articles by Kettmann, R. Search for Related Content PubMed PubMed Citation Articles by Twizere, J.-C. Articles by Kettmann, R. Related Collections Immunobiology Oncogenes and Tumor Suppressors Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling Jean-Claude Twizere1, Jean-Yves Springael2, Mathieu Boxus1, Arsène Burny1, Franck Dequiedt1, Jean-François Dewulf1, Julie Duchateau1, Daniel Portetelle1, Patrice Urbain1, Carine Van Lint3, Patrick L. Green4, Renaud Mahieux5, Marc Parmentier2, Luc Willems1, and Richard Kettmann1 1 Department of Cellular and Molecular Biology, Faculty of Gembloux, Gembloux, Belgium; 2 Institut de Recherche en Biologie Humaine et Moléculaire, Université Libre de Bruxelles Campus Erasme, Brussels, Belgium; 3 Laboratoire de Virologie Moléculaire, Institut de Biologie et de Médecine Moléculaires (IBMM), Service de Chimie Biologique, Université Libre de Bruxelles, Gosselies, Belgium; 4 Department of Veterinary Biosciences and Molecular Virology Immunology and Department of Medical Genetics, Center for Retrovirus Research, Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH; and 5 Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France Human T-cell leukemia virus type-1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and neurological syndromes. HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation. Guanine nucleotide–binding proteins (G proteins) and G protein–coupled receptors (GPCRs) constitute the largest family of membrane proteins known and are involved in the regulation of most biological functions. Here, we report an interaction between HTLV-1 Tax oncoprotein and the G-protein ß subunit. Interestingly, though the G-protein ß subunit inhibits Tax-mediated viral transcription, Tax-1 perturbs G-protein ß subcellular localization. Functional evidence for these observations was obtained using conditional Tax-1–expressing transformed T-lymphocytes, where Tax expression correlated with activation of the SDF-1/CXCR4 axis. Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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