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Blood, 15 February 2007, Vol. 109, No. 4, pp. 1602-1610. Prepublished online as a Blood First Edition Paper on October 3, 2006; DOI 10.1182/blood-2006-04-018465. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-04-018465v1 109/4/1602    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kim, M.-Y. Articles by Lane, P. J. L. Search for Related Content PubMed PubMed Citation Articles by Kim, M.-Y. Articles by Lane, P. J. L. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Function of CD4+CD3– cells in relation to B- and T-zone stroma in spleen Mi-Yeon Kim1, Fiona M. McConnell1, Fabrina M. C. Gaspal1, Andrea White1, Stephanie H. Glanville1, Vasilios Bekiaris1, Lucy S. K. Walker1, Jorge Caamano1, Eric Jenkinson1, Graham Anderson1, and Peter J. L. Lane1 1 Medical Research Council (MRC) Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, United Kingdom Lymphocytes from lymphotoxin (LT) –deficient mice, which lack segregation of their B- and T-cell areas, acquire normal organization following adoptive transfer into RAG-deficient recipients, identifying a non-B non-T cell in the segregation process. Here we show that a CD4+CD3– accessory cell is tightly associated with discrete VCAM-1–expressing stromal cells in B- and T-cell areas of the mouse spleen. CD4+CD3– cells express high levels of LT, LTß, and tumor necrosis factor (TNF) , which are the ligands for the LTß receptor and TNFR1 expressed by stromal cells. The expression of these ligands is functional, as transferring CD4+CD3– cells derived from either embryonic or adult tissues into LT-deficient mice organizes B/T segregation and up-regulates CCL21 protein expression in areas where T cells are segregated from B cells. We propose that the function of CD4+CD3– cells is to form a link between primed CD4 T cells and the underlying stromal elements, creating distinct microenvironments in which they enable effector responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. H. Ruddle and E. M. Akirav Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response J. Immunol., August 15, 2009; 183(4): 2205 - 2212. [Abstract] [Full Text] [PDF] S. Schmutz, N. Bosco, S. Chappaz, O. Boyman, H. Acha-Orbea, R. Ceredig, A. G. Rolink, and D. Finke Cutting Edge: IL-7 Regulates the Peripheral Pool of Adult ROR{gamma}+ Lymphoid Tissue Inducer Cells J. Immunol., August 15, 2009; 183(4): 2217 - 2221. [Abstract] [Full Text] [PDF] V. Bekiaris, F. Gaspal, M.-Y. Kim, D. R. Withers, F. M. McConnell, G. Anderson, and P. J. L. Lane CD30 Is Required for CCL21 Expression and CD4 T Cell Recruitment in the Absence of Lymphotoxin Signals J. Immunol., April 15, 2009; 182(8): 4771 - 4775. [Abstract] [Full Text] [PDF] H. Takatori, Y. Kanno, W. T. Watford, C. M. Tato, G. Weiss, I. I. Ivanov, D. R. Littman, and J. J. O'Shea Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22 J. Exp. Med., January 16, 2009; 206(1): 35 - 41. [Abstract] [Full Text] [PDF] M. F. R. Vondenhoff, G. E. Desanti, T. Cupedo, J. Y. Bertrand, A. Cumano, G. Kraal, R. E. Mebius, and R. Golub Separation of splenic red and white pulp occurs before birth in a LT{alpha}{beta}-independent manner J. Leukoc. Biol., July 1, 2008; 84(1): 152 - 161. [Abstract] [Full Text] [PDF] V. Bekiaris, O. Timoshenko, T. Z. Hou, K. Toellner, S. Shakib, F. Gaspal, F. M. McConnell, S. M. Parnell, D. Withers, C. D. Buckley, et al. Ly49H+ NK Cells Migrate to and Protect Splenic White Pulp Stroma from Murine Cytomegalovirus Infection J. Immunol., May 15, 2008; 180(10): 6768 - 6776. [Abstract] [Full Text] [PDF] F. Gaspal, V. Bekiaris, M.-Y. Kim, D. R. Withers, S. Bobat, I. C. M. MacLennan, G. Anderson, P. J. Lane, and A. F. Cunningham Critical Synergy of CD30 and OX40 Signals in CD4 T Cell Homeostasis and Th1 Immunity to Salmonella J. Immunol., March 1, 2008; 180(5): 2824 - 2829. [Abstract] [Full Text] [PDF] V. Bekiaris, D. Withers, S. H. Glanville, F. M. McConnell, S. M. Parnell, M.-Y. Kim, F. M. C. Gaspal, E. Jenkinson, C. Sweet, G. Anderson, et al. Role of CD30 in B/T Segregation in the Spleen J. Immunol., December 1, 2007; 179(11): 7535 - 7543. [Abstract] [Full Text] [PDF] J. Qin, H. Konno, D. Ohshima, H. Yanai, H. Motegi, Y. Shimo, F. Hirota, M. Matsumoto, S. Takaki, J.-i. Inoue, et al. Developmental Stage-Dependent Collaboration between the TNF Receptor-Associated Factor 6 and Lymphotoxin Pathways for B Cell Follicle Organization in Secondary Lymphoid Organs J. Immunol., November 15, 2007; 179(10): 6799 - 6807. [Abstract] [Full Text] [PDF] S. W. Rossi, M.-Y. Kim, A. Leibbrandt, S. M. Parnell, W. E. Jenkinson, S. H. Glanville, F. M. McConnell, H. S. Scott, J. M. Penninger, E. J. Jenkinson, et al. RANK signals from CD4+3 inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla J. Exp. Med., June 11, 2007; 204(6): 1267 - 1272. [Abstract] [Full Text] [PDF]

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