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Blood, 15 February 2007, Vol. 109, No. 4, pp. 1743-1751. Prepublished online as a Blood First Edition Paper on October 24, 2006; DOI 10.1182/blood-2005-11-010504. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2005-11-010504v1 109/4/1743    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gang, E. J. Articles by Perlingeiro, R. C. R. Search for Related Content PubMed PubMed Citation Articles by Gang, E. J. Articles by Perlingeiro, R. C. R. Related Collections Hematopoiesis and Stem Cells Stem Cells in Hematology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  STEM CELLS IN HEMATOLOGY SSEA-4 identifies mesenchymal stem cells from bone marrow Eun J. Gang1, Darko Bosnakovski1, Camila A. Figueiredo1, Jan W. Visser2, and Rita C. R. Perlingeiro1,2 1 Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX; 2 ViaCell, Cambridge, MA Adult bone marrow (BM) contains hematopoietic stem cells (HSCs) as well as a nonhematopoietic, stromal cell population. Within this stromal population are mesenchymal stem cells (MSCs), which not only support hematopoiesis but also differentiate into multiple lineages, including fat, bone, and cartilage. Because of this multipotentiality, the MSC is an attractive candidate for clinical applications to repair or regenerate damaged tissues of mesenchymal origin. However, research progress has been hampered by the limited existing knowledge of the biology of these cells, particularly by the lack of a suitable marker for their prospective isolation. Here, we report that SSEA-4, an early embryonic glycolipid antigen commonly used as a marker for undifferentiated pluripotent human embryonic stem cells and cleavage to blastocyst stage embryos, also identifies the adult mesenchymal stem cell population. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Karystinou, F. Dell'Accio, T. B. A. Kurth, H. Wackerhage, I. M. Khan, C. W. Archer, E. A. Jones, T. A. Mitsiadis, and C. De Bari Distinct mesenchymal progenitor cell subsets in the adult human synovium Rheumatology, September 1, 2009; 48(9): 1057 - 1064. [Abstract] [Full Text] [PDF] V. L. Battula, S. Treml, P. M. Bareiss, F. Gieseke, H. Roelofs, P. de Zwart, I. Muller, B. Schewe, T. Skutella, W. E. Fibbe, et al. Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1 Haematologica, February 1, 2009; 94(2): 173 - 184. [Abstract] [Full Text] [PDF] M. A. Haniffa, M. P. Collin, C. D. Buckley, and F. Dazzi Mesenchymal stem cells: the fibroblasts' new clothes? Haematologica, February 1, 2009; 94(2): 258 - 263. [Abstract] [Full Text] [PDF] R. H. Lee, M. J. Seo, A. A. Pulin, C. A. Gregory, J. Ylostalo, and D. J. Prockop The CD34-like protein PODXL and {alpha}6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice Blood, January 22, 2009; 113(4): 816 - 826. [Abstract] [Full Text] [PDF] C. R. Walkley, R. Qudsi, V. G. Sankaran, J. A. Perry, M. Gostissa, S. I. Roth, S. J. Rodda, E. Snay, P. Dunning, F. H. Fahey, et al. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease Genes & Dev., June 15, 2008; 22(12): 1662 - 1676. [Abstract] [Full Text] [PDF] B. Delorme, J. Ringe, N. Gallay, Y. Le Vern, D. Kerboeuf, C. Jorgensen, P. Rosset, L. Sensebe, P. Layrolle, T. Haupl, et al. Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells Blood, March 1, 2008; 111(5): 2631 - 2635. [Abstract] [Full Text] [PDF] E. Jones and D. McGonagle Human bone marrow mesenchymal stem cells in vivo Rheumatology, February 1, 2008; 47(2): 126 - 131. [Abstract] [Full Text] [PDF] J. Murphy, R. Summer, and A. Fine Stem Cells in Airway Smooth Muscle: State of the Art Proceedings of the ATS, January 1, 2008; 5(1): 11 - 14. [Abstract] [Full Text] [PDF]

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