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Blood, 1 March 2007, Vol. 109, No. 5, pp. 1931-1937. Prepublished online as a Blood First Edition Paper on November 2, 2006; DOI 10.1182/blood-2006-07-037283. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-07-037283v1 109/5/1931    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maroney, S. A. Articles by Mast, A. E. Search for Related Content PubMed PubMed Citation Articles by Maroney, S. A. Articles by Mast, A. E. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Active tissue factor pathway inhibitor is expressed on the surface of coated platelets Susan A. Maroney1, Sandra L. Haberichter2, Paul Friese3, Maureen L. Collins1, Josephine P. Ferrel1, George L. Dale3, and Alan E. Mast1 1 Blood Research Institute, Blood Center of Wisconsin, Milwaukee; 2 Department of Pediatrics, The Medical College of Wisconsin, Milwaukee; 3 Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City The incorporation of blood-borne forms of tissue factor (TF) into a growing blood clot is necessary for normal fibrin generation and stabilization of the blood clot. Tissue factor pathway inhibitor (TFPI) is the primary physiologic inhibitor of tissue factor and is present within platelets. Expression of TFPI on the platelet surface may be the optimal location for it to abrogate blood-borne TF activity that incorporates within the blood clot, balancing the need for adequate hemostasis while preventing development of occlusive thrombosis. TFPI is produced by megakaryocytes but is not expressed on the platelet surface. Activation of platelets with thrombin receptor activation peptide does not cause release or surface expression of TFPI, demonstrating that TFPI is not stored within platelet granules. TFPI is expressed on the platelet surface following dual-agonist activation with convulxin plus thrombin to produce coated platelets. In association with its expression on the surface of coated platelets TFPI is also released in microvesicles or as a soluble protein. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Duckers, P. Simioni, L. Spiezia, C. Radu, S. Gavasso, J. Rosing, and E. Castoldi Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency Blood, November 1, 2008; 112(9): 3615 - 3623. [Abstract] [Full Text] [PDF] J. T.B. Crawley and D. A. Lane The Haemostatic Role of Tissue Factor Pathway Inhibitor Arterioscler Thromb Vasc Biol, February 1, 2008; 28(2): 233 - 242. [Abstract] [Full Text] [PDF] S. M. Jobe, K. M. Wilson, L. Leo, A. Raimondi, J. D. Molkentin, S. R. Lentz, and J. Di Paola Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis Blood, February 1, 2008; 111(3): 1257 - 1265. [Abstract] [Full Text] [PDF]

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