SEARCH:   Advanced

Blood, 1 March 2007, Vol. 109, No. 5, pp. 2023-2031. Prepublished online as a Blood First Edition Paper on October 31, 2006; DOI 10.1182/blood-2006-05-021600. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-021600v1 109/5/2023    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fröhlich, A. Articles by Kopf, M. Search for Related Content PubMed PubMed Citation Articles by Fröhlich, A. Articles by Kopf, M. Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo Anja Fröhlich1, Benjamin J. Marsland1, Ivo Sonderegger1, Michael Kurrer2, Martin R. Hodge3, Nicola L. Harris4, and Manfred Kopf1 1 Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology (ETH) Zürich, Switzerland; 2 Deparment of Pathology, University of Zürich, Switzerland; 3 Inflammation Division, Millennium Pharmaceuticals, Cambridge, MA; 4 Institute of Integrative Biology, Environmental Biomedicine, ETH Zürich, Switzerland Interleukin 21 (IL-21) is a member of the common -chain family of cytokines, which influence a broad spectrum of immunologic responses. A number of studies have examined the function of IL-21, but its specific role in Th1/Th2-cell differentiation and related effector responses remains to be clarified. Thus, we generated IL-21R–deficient mice and have investigated the role of IL-21R signaling using a series of in vivo experimentally induced disease models. We first addressed the role of IL-21R signaling in Th2 immune responses by examining allergic airway inflammation, and Nippostrongylus brasiliensis and Heligmosomoides polygyrus antihelminth responses. In each of these systems, IL-21R signaling played a clear role in the development of Th2 responses. Comparatively, IL-21R signaling was not required for the containment of Leishmania major infection or the development of experimental autoimmune myocarditis, indicative of competent Th1 and Th17 responses, respectively. Adoptive transfer of T cells and analysis of IL-21R+/+/IL-21R–/– chimera mice revealed that IL-21R–signaling was central to Th2-cell survival or migration to peripheral tissues. Overall, our data show IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. R. Ramalingam, J. T. Pesce, M. M. Mentink-Kane, S. Madala, A. W. Cheever, M. R. Comeau, S. F. Ziegler, and T. A. Wynn Regulation of Helminth-Induced Th2 Responses by Thymic Stromal Lymphopoietin J. Immunol., May 15, 2009; 182(10): 6452 - 6459. [Abstract] [Full Text] [PDF] A. G. Zaretsky, J. J. Taylor, I. L. King, F. A. Marshall, M. Mohrs, and E. J. Pearce T follicular helper cells differentiate from Th2 cells in response to helminth antigens J. Exp. Med., May 11, 2009; 206(5): 991 - 999. [Abstract] [Full Text] [PDF] F. Eddahri, S. Denanglaire, F. Bureau, R. Spolski, W. J. Leonard, O. Leo, and F. Andris Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities Blood, March 12, 2009; 113(11): 2426 - 2433. [Abstract] [Full Text] [PDF] A. K. Heer, N. L. Harris, M. Kopf, and B. J. Marsland CD4+ and CD8+ T Cells Exhibit Differential Requirements for CCR7-Mediated Antigen Transport during Influenza Infection J. Immunol., November 15, 2008; 181(10): 6984 - 6994. [Abstract] [Full Text] [PDF] W. J. Leonard, R. Zeng, and R. Spolski Interleukin 21: a cytokine/cytokine receptor system that has come of age J. Leukoc. Biol., August 1, 2008; 84(2): 348 - 356. [Abstract] [Full Text] [PDF] B. Gangadharan, M. A. Hoeve, J. E. Allen, B. Ebrahimi, S. M. Rhind, B. M. Dutia, and A. A. Nash Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages J. Leukoc. Biol., July 1, 2008; 84(1): 50 - 58. [Abstract] [Full Text] [PDF] J. M. Coquet, S. Chakravarti, M. J. Smyth, and D. I. Godfrey Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis J. Immunol., June 1, 2008; 180(11): 7097 - 7101. [Abstract] [Full Text] [PDF] L. E. Clough, C. J. Wang, E. M. Schmidt, G. Booth, T. Z. Hou, G. A. Ryan, and L. S. K. Walker Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21 J. Immunol., April 15, 2008; 180(8): 5393 - 5401. [Abstract] [Full Text] [PDF] I. D. Davis, K. Skak, M. J. Smyth, P. E.G. Kristjansen, D. M. Miller, and P. V. Sivakumar Interleukin-21 Signaling: Functions in Cancer and Autoimmunity Clin. Cancer Res., December 1, 2007; 13(23): 6926 - 6932. [Abstract] [Full Text] [PDF] L. Wei, A. Laurence, K. M. Elias, and J. J. O'Shea IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner J. Biol. Chem., November 30, 2007; 282(48): 34605 - 34610. [Abstract] [Full Text] [PDF] T. Onoda, M. Rahman, H. Nara, A. Araki, K. Makabe, K. Tsumoto, I. Kumagai, T. Kudo, N. Ishii, N. Tanaka, et al. Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets Int. Immunol., October 1, 2007; 19(10): 1191 - 1199. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020