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Blood, 1 March 2007, Vol. 109, No. 5, pp. 2058-2065. Prepublished online as a Blood First Edition Paper on November 16, 2006; DOI 10.1182/blood-2006-04-016451. This Article Full Text Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2006-04-016451v1 109/5/2058    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Garín, M. I. Articles by Lechler, R. I. Search for Related Content PubMed PubMed Citation Articles by Garín, M. I. Articles by Lechler, R. I. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells Marina I. Garín1,5, Chung-Ching Chu1, Dela Golshayan1,2, Eva Cernuda-Morollón3, Robin Wait4, and Robert I. Lechler1 1 Immunoregulation Laboratory, Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, United Kingdom; 2 Division of Nephrology and Transplant Centre, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; 3 Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom; 4 Kennedy Institute of Rheumatology, Arthritis Research Campaign Building, Faculty of Medicine, Imperial College London, United Kingdom; 5 Laboratorio de Hematopoyesis y Terapia Génica, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of ß-galactoside–binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4+CD25+ T cells. Reduced regulatory activity was observed in CD4+CD25+ T cells obtained from galectin-1–homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Lahl, C. T. Mayer, T. Bopp, J. Huehn, C. Loddenkemper, G. Eberl, G. Wirnsberger, K. Dornmair, R. Geffers, E. Schmitt, et al. Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice J. Immunol., November 1, 2009; 183(9): 5662 - 5672. [Abstract] [Full Text] [PDF] S. Sakaguchi, K. Wing, Y. Onishi, P. Prieto-Martin, and T. Yamaguchi Regulatory T cells: how do they suppress immune responses? Int. Immunol., October 1, 2009; 21(10): 1105 - 1111. [Abstract] [Full Text] [PDF] P. B. Olkhanud, D. Baatar, M. Bodogai, F. Hakim, R. Gress, R. L. Anderson, J. Deng, M. Xu, S. Briest, and A. Biragyn Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells Cancer Res., July 15, 2009; 69(14): 5996 - 6004. [Abstract] [Full Text] [PDF] C. Wu, U. Rauch, E. Korpos, J. Song, K. Loser, P. R. Crocker, and L. M. Sorokin Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression J. Immunol., May 15, 2009; 182(10): 6508 - 6516. [Abstract] [Full Text] [PDF] L. V Norling, M. Perretti, and D. Cooper Endogenous galectins and the control of the host inflammatory response J. Endocrinol., May 1, 2009; 201(2): 169 - 184. [Abstract] [Full Text] [PDF] K. Loser, A. Sturm, M. Voskort, V. Kupas, S. Balkow, M. Auriemma, C. Sternemann, A. U. Dignass, T. A. Luger, and S. Beissert Galectin-2 Suppresses Contact Allergy by Inducing Apoptosis in Activated CD8+ T Cells J. Immunol., May 1, 2009; 182(9): 5419 - 5429. [Abstract] [Full Text] [PDF] J. Wang, Z.-H. Lu, H.-J. Gabius, C. Rohowsky-Kochan, R. W. Ledeen, and G. Wu Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis J. Immunol., April 1, 2009; 182(7): 4036 - 4045. [Abstract] [Full Text] [PDF] M. J. Perone, S. Bertera, W. J. Shufesky, S. J. Divito, A. Montecalvo, A. R. Mathers, A. T. Larregina, M. Pang, N. Seth, K. W. Wucherpfennig, et al. Suppression of Autoimmune Diabetes by Soluble Galectin-1 J. Immunol., March 1, 2009; 182(5): 2641 - 2653. [Abstract] [Full Text] [PDF] S. J. Tabrizi, H. Niiro, M. Masui, G. Yoshimoto, T. Iino, Y. Kikushige, T. Wakasaki, E. Baba, S. 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