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Blood, 1 March 2007, Vol. 109, No. 5, pp. 2078-2085. Prepublished online as a Blood First Edition Paper on September 14, 2006; DOI 10.1182/blood-2006-06-028985. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-06-028985v1 109/5/2078    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Catellani, S. Articles by Zocchi, M. R. Search for Related Content PubMed PubMed Citation Articles by Catellani, S. Articles by Zocchi, M. R. Related Collections Immunobiology Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Expansion of V1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16–binding proteins Silvia Catellani1, Alessandro Poggi2, Andrea Bruzzone3, Patrizia Dadati4, Jean Louis Ravetti4, Marco Gobbi5, and Maria Raffaella Zocchi6 1 Laboratory of Hematology, University of Genoa, Genoa, Italy; 2 Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy; 3 Department of Internal Medicine, University of Genoa, Genoa, Italy; 4 Department of Pathology, San Martino Hospital, University of Genoa, Genoa, Italy; 5 Laboratory of Clinical Hematology, University of Genoa, Genoa, Italy; and 6 Laboratory of Tumor Immunology, San Raffaele Scientific Institute, Milan, Italy. Data on 23 patients with low-grade non-Hodgkin lymphomas (NHLs), 4 mantle (MT), 4 marginal zone (MZ), and 15 follicular (FL), were analyzed and compared with 10 high-risk (HR) B-cell chronic lymphocytic leukemias (B-CLLs) with lymph node involvement and 4 diffuse large-cell lymphomas (DLCLs). A significant increase in circulating V1 T lymphocytes producing interleukin-4 (IL-4) was found in patients with FL, MT, and MZ NHL, at variance with DLCL and HR B-CLL. IL-4 was also detectable in the sera and lymph nodes of the same patients. In 19 of the 23 patients with NHL with increased circulating V1 T lymphocytes, B cells expressing the UL-16–binding proteins (ULBPs) ULBP2 or ULBP3 or both were found in peripheral blood, bone marrow, or lymph nodes. Of note, in HR B-CLL or in DLCL, where leukemic cells were negative for ULBPs, no V1 T-cell increase was found. Moreover, V1 T lymphocytes from patients with FL NHL proliferate in response to ULBP2+ and ULBP3+ lymphoma cells. Finally, patients with high expression of ULBPs, increased circulating V1 T lymphocytes, and high levels of serum IL-4 showed stable disease in a 1-year follow-up in contrast to patients with low circulating V1 T cells and undetectable IL-4 or ULBPs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Kong, W. Cao, X. Xi, C. Ma, L. Cui, and W. He The NKG2D ligand ULBP4 binds to TCR{gamma}9/{delta}2 and induces cytotoxicity to tumor cells through both TCR{gamma}{delta} and NKG2D Blood, July 9, 2009; 114(2): 310 - 317. [Abstract] [Full Text] [PDF] M. Todaro, M. D'Asaro, N. Caccamo, F. Iovino, M. G. Francipane, S. Meraviglia, V. Orlando, C. La Mendola, G. Gulotta, A. Salerno, et al. Efficient Killing of Human Colon Cancer Stem Cells by {gamma}{delta} T Lymphocytes J. Immunol., June 1, 2009; 182(11): 7287 - 7296. [Abstract] [Full Text] [PDF] N. L. Bryant, C. Suarez-Cuervo, G. Y. Gillespie, J. M. Markert, L. B. Nabors, S. Meleth, R. D. Lopez, and L. S. Lamb Jr. Characterization and immunotherapeutic potential of {gamma}{delta} T-cells in patients with glioblastoma Neuro-oncol, January 1, 2009; 11(4): 357 - 367. [Abstract] [Full Text] [PDF]

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