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Blood, 1 March 2007, Vol. 109, No. 5, pp. 2086-2088. Prepublished online as a Blood First Edition Paper on October 19, 2006; DOI 10.1182/blood-2006-06-031385. This Article Full Text Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2006-06-031385v1 109/5/2086    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Malaspina, A. Articles by Fauci, A. S. Search for Related Content PubMed PubMed Citation Articles by Malaspina, A. Articles by Fauci, A. S. Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief Report Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7 Angela Malaspina1, Susan Moir1, Doreen G. Chaitt1, Catherine A. Rehm1, Shyam Kottilil1, Judith Falloon1, and Anthony S. Fauci1 1 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD Idiopathic CD4+ T lymphocytopenia (ICL) is a rare heterogeneous disorder defined by CD4+ T-cell counts below 300 cells/µL in the absence of human immunodeficiency virus (HIV) infection or other known immune deficiency disorders. Here, we report the expansion of immature/transitional B cells in patients with ICL, which is associated with elevated serum levels of IL-7. Both the percentage of immature/transitional B cells and levels of IL-7 were inversely correlated with levels of CD4+ T-cell counts and directly correlated to each other. Further analyses of B cells indicated that, in contrast to the activating effects of HIV disease on mature B cells, the expansion of immature/transitional B cells in patients with ICL occurred at the expense of memory B cells. These findings extend previous reports on primary immunodeficiencies as well as HIV disease by suggesting that CD4+ T-cell lymphopenia has an impact on human B-cell development either directly or indirectly via the associated elevation of IL-7 levels. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. I. Zonios, J. Falloon, J. E. Bennett, P. A. Shaw, D. Chaitt, M. W. Baseler, J. W. Adelsberger, J. A. Metcalf, M. A. Polis, S. J. Kovacs, et al. Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors Blood, July 15, 2008; 112(2): 287 - 294. [Abstract] [Full Text] [PDF] S. Moir, J. Ho, A. Malaspina, W. Wang, A. C. DiPoto, M. A. O'Shea, G. Roby, S. Kottilil, J. Arthos, M. A. Proschan, et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals J. Exp. Med., July 14, 2008; (2008) jem.20072683. [Abstract] [Full Text] [PDF] C. Wehr, T. Kivioja, C. Schmitt, B. Ferry, T. Witte, E. Eren, M. Vlkova, M. Hernandez, D. Detkova, P. R. Bos, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency Blood, January 1, 2008; 111(1): 77 - 85. [Abstract] [Full Text] [PDF] K. V. Komanduri, L. S. St. John, M. de Lima, J. McMannis, S. Rosinski, I. McNiece, S. G. Bryan, I. Kaur, S. Martin, E. D. Wieder, et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing Blood, December 15, 2007; 110(13): 4543 - 4551. [Abstract] [Full Text] [PDF]

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