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Blood, 1 March 2007, Vol. 109, No. 5, pp. 2183-2189. Prepublished online as a Blood First Edition Paper on October 31, 2006; DOI 10.1182/blood-2006-07-033142. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2006-07-033142v1 109/5/2183    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bossard, C. Articles by Gaulard, P. Search for Related Content PubMed PubMed Citation Articles by Bossard, C. Articles by Gaulard, P. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials Céline Bossard1, Karim Belhadj2, Felix Reyes2, Nadine Martin-Garcia1, Françoise Berger3, Jean Alain Kummer4, Josette Brière5, Anne-Catherine Baglin6, Stéphane Cheze7, Jacques Bosq8, Vincent Ribrag9, Christian Gisselbrecht10, Nicolas Mounier10, and Philippe Gaulard1 1 Département de Pathologie and Institut National de la Santé et de la Recherche Médicale (Inserm) Unité (U) 617, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France; 2 Service d'Hématologie Clinique, Hôpital Henri Mondor, Créteil, France; 3 Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalier Lyon Sud, Pierre Bénite, France; 4 Department of Pathology, University Medical Center Utrecht, The Netherlands; 5 Département de Pathologie, Hôpital Saint-Louis, Paris, France; 6 Département de Pathologie, Hôpital Foch, Suresnes, France; 7 Service d'Hématologie Clinique, Hôpital Clemenceau, Caen, France; 8 Département de Pathologie, Institut Gustave Roussy, Villejuif, France; 9 Département de Médecine, Institut Gustave Roussy, Villejuif, France; 10 Institut d'Hématologie, Hôpital Saint-Louis, Paris, France Nasal NK/T-cell lymphoma is a rare disease entity with a poor outcome. Expression of antiapoptotic proteins has not been extensively investigated in this entity. Forty-eight patients with nasal T/NK-cell lymphoma who received first-line polychemotherapy (n = 44) or chemoradiotherapy (n = 4) were analyzed for expression of active caspase-3 (aC3), granzyme B protease inhibitor 9 (PI9), and Bcl-2 proteins. Lymphomas were CD3+/CD5–/granzyme B+ and EBV-associated. Median age was 46 years. Stage I/II disease was present in 75% of the cases and an International Prognostic Index (IPI) score less than 1 in 65%. With a median follow-up of 6.3 years, 5-year event-free survival (EFS) and overall survival (OS) rates were 39% and 49%, respectively. Apoptotic index was scored as high in 32% of cases and PI9 expression as positive in 68%, whereas 35% disclosed a high number of aC3+ tumor cells. Univariate analysis showed that absence of PI9 and low apoptotic index were associated with poor outcome, but not aC3 expression nor IPI score. By multivariate analysis, both parameters affected independently EFS (P = .02 and .08, respectively) and OS (P = .009 and .04). In view of its constitutive expression by normal NK cells, it is suggested that loss of PI9 expression in tumor cells may reflect some mechanism associated with progression. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. Y. Kim, Y. K. Jeon, T. M. Kim, J. E. Kim, Y. A. Kim, S.-H. Lee, D.-W. Kim, D. S. Heo, and C.-W. Kim Increased quantity of tumor-infiltrating FOXP3-positive regulatory T cells is an independent predictor for improved clinical outcome in extranodal NK/T-cell lymphoma Ann. Onc., October 1, 2009; 20(10): 1688 - 1696. [Abstract] [Full Text] [PDF] Y.-X. Li, Q.-F. Liu, H. Fang, S.-N. Qi, H. Wang, W.-H. Wang, Y.-W. Song, J. Lu, J. Jin, S.-L. Wang, et al. Variable Clinical Presentations of Nasal and Waldeyer Ring Natural Killer/T-Cell Lymphoma Clin. Cancer Res., April 15, 2009; 15(8): 2905 - 2912. [Abstract] [Full Text] [PDF] Y.-X. Li, H. Fang, Q.-F. Liu, J. Lu, S.-N. Qi, H. Wang, J. Jin, W.-H. Wang, Y.-P. Liu, Y.-W. Song, et al. Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring Blood, October 15, 2008; 112(8): 3057 - 3064. [Abstract] [Full Text] [PDF]

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