Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 March 2007, Vol. 109, No. 6, pp. 2327-2330.
Prepublished online as a Blood First Edition Paper on November 9, 2006; DOI 10.1182/blood-2006-08-040436.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Appendix
Right arrow All Versions of this Article:
blood-2006-08-040436v1
109/6/2327    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moorman, A. V.
Right arrow Articles by Harrison, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moorman, A. V.
Right arrow Articles by Harrison, C. J.
Related Collections
Right arrow Neoplasia
Right arrow Brief Reports
Right arrow Clinical Trials and Observations
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

CLINICAL TRIALS AND OBSERVATIONS

Brief Report

Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)

Anthony V. Moorman1, Susan M. Richards2, Hazel M. Robinson1, Jon C. Strefford1, Brenda E. S. Gibson3, Sally E. Kinsey4, Tim O. B. Eden5, Ajay J. Vora6, Christopher D. Mitchell7, Christine J. Harrison1, on behalf of the UK Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)

1 Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom; 2 Clinical Trial Service Unit, University of Oxford, United Kingdom; 3 Department of Haematology, Yorkhill National Health Service (NHS) Trust, Glasgow, United Kingdom; 4 Department of Haematology, St James Hospital, Leeds, United Kingdom; 5 Academic Unit of Paediatric and Adolescent Oncology, University of Manchester, Christie Hospital and Central Manchester Children's University Hospitals Trusts, United Kingdom; 6 Department of Haematology, Sheffield Children's Hospital, United Kingdom; 7 John Radcliffe Hospital, Oxford, United Kingdom

Patients with acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup. We prospectively screened 1630 (84%) patients treated on the UK MRC ALL97 protocol for iAMP21 and herein present demographic, clinical, and survival data on the 28 (2%) children found to harbor this abnormality. They had a common or pre-B ALL immunophenotype, were significantly older (median 9 years vs 5 years), and had a lower white cell count (median 3.9 vs 12.4) compared with children without this abnormality. Notably, patients with iAMP21 had a significantly inferior event-free and overall survival at 5 years compared with other patients: 29% (95% confidence interval [CI], 13%-48%) versus 78% (95% CI, 76%-80%) and 71% (95% CI, 51%-84%) versus 87% (95% CI, 85%-88%), respectively. As a result of this 3-fold increase in relapse risk, newly diagnosed patients with iAMP21 recruited to the current UK MRC ALL2003 trial are being treated on the high-risk arm and are considered for bone marrow transplantation in first remission.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
L. J. Russell, M. Capasso, I. Vater, T. Akasaka, O. A. Bernard, M. J. Calasanz, T. Chandrasekaran, E. Chapiro, S. Gesk, M. Griffiths, et al.
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
Blood, September 24, 2009; 114(13): 2688 - 2698.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. G. Mullighan, L. A. Phillips, X. Su, J. Ma, C. B. Miller, S. A. Shurtleff, and J. R. Downing
Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia
Science, November 28, 2008; 322(5906): 1377 - 1380.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Attarbaschi, G. Mann, R. Panzer-Grumayer, S. Rottgers, M. Steiner, M. Konig, E. Csinady, M. N. Dworzak, M. Seidel, D. Janousek, et al.
Minimal Residual Disease Values Discriminate Between Low and High Relapse Risk in Children With B-Cell Precursor Acute Lymphoblastic Leukemia and an Intrachromosomal Amplification of Chromosome 21: The Austrian and German Acute Lymphoblastic Leukemia Berlin-Frankfurt-Munster (ALL-BFM) Trials
J. Clin. Oncol., June 20, 2008; 26(18): 3046 - 3050.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Paulsson, J.-B. Cazier, F. MacDougall, J. Stevens, I. Stasevich, N. Vrcelj, T. Chaplin, D. M. Lillington, T. A. Lister, and B. D. Young
Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease
PNAS, May 6, 2008; 105(18): 6708 - 6713.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020