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Blood, 15 March 2007, Vol. 109, No. 6, pp. 2339-2345. Prepublished online as a Blood First Edition Paper on November 21, 2006; DOI 10.1182/blood-2006-05-021089.
HEMATOPOIESIS Naive recirculating B cells mature simultaneously in the spleen and bone marrow1 Massachusetts General Hospital and Harvard Medical School, Boston
We have recently demonstrated that IgDhi B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgDhi naive recirculating B cells, but the existence of mutant mice that have selectively lost mature B cells in the bone marrow prompted an examination of B-cell maturation at this latter site. Following a single pulse of BrdU in intact mice, sequential labeling of more mature B-cell populations in the bone marrow suggested ongoing maturation at this site. Further evidence for B-cell maturation in the bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin
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| Copyright © 2007 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
-deficient mice that lack all secondary lymphoid organs. In these mice, antibody-secreting cells recognizing multivalent antigens were also observed in the bone marrow following an intravenous microbial challenge. These data suggest that newly formed B cells mature into IgDhi B cells simultaneously in the spleen and the bone marrow and establish in a stringent manner that humoral immune responses can be initiated in situ in the bone marrow. 
