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Blood, 15 March 2007, Vol. 109, No. 6, pp. 2553-2556. Prepublished online as a Blood First Edition Paper on November 7, 2006; DOI 10.1182/blood-2006-07-037960. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2006-07-037960v1 109/6/2553    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sochorová, K. Articles by Spísek, R. Search for Related Content PubMed PubMed Citation Articles by Sochorová, K. Articles by Spísek, R. Related Collections Immunobiology Brief Reports Chemokines, Cytokines, and Interleukins Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief Report Impaired Toll-like receptor 8–mediated IL-6 and TNF- production in antigen-presenting cells from patients with X-linked agammaglobulinemia Klára Sochorová1, Rudolf Horváth1, Daniela Roková1, Jií Litzman2, Jiina Bartková1, Anna edivá1, and Radek píek1 1 Institute of Immunology, Charles University, 2nd Medical School, Prague, Czech Republic; 2 Department of Clinical Immunology and Allergology, Masaryk University, Brno, Czech Republic The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF- production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Bruton tyrosine kinase (Btk): key for signaling via Toll-like receptor 8 Ofer Levy Blood 2007 109: 2273-2274. [Full Text] [PDF] This article has been cited by other articles: K.-G. Lee, S. Xu, E.-T. Wong, V. Tergaonkar, and K.-P. Lam Bruton's Tyrosine Kinase Separately Regulates NF{kappa}B p65RelA Activation and Cytokine Interleukin (IL)-10/IL-12 Production in TLR9-stimulated B Cells J. Biol. Chem., April 25, 2008; 283(17): 11189 - 11198. [Abstract] [Full Text] [PDF] T. Marafioti, J. C. Paterson, E. Ballabio, K. K. Reichard, S. Tedoldi, K. Hollowood, M. Dictor, M.-L. Hansmann, S. A. Pileri, M. J. Dyer, et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells Blood, April 1, 2008; 111(7): 3778 - 3792. [Abstract] [Full Text] [PDF] C. D. Palmer, B. E. Mutch, S. Workman, J. P. McDaid, N. J. Horwood, and B. M. J. Foxwell Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NF{kappa}B activity Blood, February 15, 2008; 111(4): 1781 - 1788. [Abstract] [Full Text] [PDF] S. L. Doyle, C. A. Jefferies, C. Feighery, and L. A. J. O'Neill Signaling by Toll-like Receptors 8 and 9 Requires Bruton's Tyrosine Kinase J. Biol. Chem., December 21, 2007; 282(51): 36953 - 36960. [Abstract] [Full Text] [PDF]

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