SEARCH:   Advanced

Blood, 1 April 2007, Vol. 109, No. 7, pp. 2823-2831. Prepublished online as a Blood First Edition Paper on November 30, 2006; DOI 10.1182/blood-2006-07-035345. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-07-035345v1 109/7/2823    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schurgers, L. J. Articles by Vermeer, C. Search for Related Content PubMed PubMed Citation Articles by Schurgers, L. J. Articles by Vermeer, C. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats Leon J. Schurgers1,2, Henri M. H. Spronk3, Berry A. M. Soute1, Paul M. Schiffers4, Jo G. R. DeMey4, and Cees Vermeer1,2 1 Cardiovascular Research Institute (CARIM), Maastricht University, The Netherlands; 2 VitaK, Maastricht University, The Netherlands; 3 Department of Internal Medicine, Cardiovascular Research Institute (CARIM), Maastricht University, The Netherlands; 4 Department of Pharmacology and Toxicology, Cardiovascular Research Institute (CARIM), Maastricht University, The Netherlands Arterial calcification (AC) is generally regarded as an independent risk factor for cardiovascular morbidity and mortality. Matrix Gla protein (MGP) is a potent inhibitor of AC, and its activity depends on vitamin K (VK). In rats, inactivation of MGP by treatment with the vitamin K antagonist warfarin leads to rapid calcification of the arteries. Here, we investigated whether preformed AC can be regressed by a VK-rich diet. Rats received a calcification-inducing diet containing both VK and warfarin (W&K). During a second 6-week period, animals were randomly assigned to receive either W&K (3.0 mg/g and 1.5 mg/g, subsequently), a diet containing a normal (5 µg/g) or high (100 µg/g) amount of VK (either K1 or K2). Increased aortic calcium concentration was observed in the group that continued to receive W&K and also in the group changed to the normal dose of VK and AC progressed. Both the VK-rich diets decreased the arterial calcium content by some 50%. In addition, arterial distensibility was restored by the VK-rich diet. Using MGP antibodies, local VK deficiency was demonstrated at sites of calcification. This is the first study in rats demonstrating that AC and the resulting decreased arterial distensibility are reversible by high-VK intake. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. C McCann and B. N Ames Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am. J. Clinical Nutrition, October 1, 2009; 90(4): 889 - 907. [Abstract] [Full Text] [PDF] B. D. Parker, J. H. Ix, E. C. M. Cranenburg, C. Vermeer, M. A. Whooley, and L. J. Schurgers Association of kidney function and uncarboxylated matrix Gla protein: Data from the Heart and Soul Study Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2095 - 2101. [Abstract] [Full Text] [PDF] M K. Shea, C. J O'Donnell, U. Hoffmann, G. E Dallal, B. Dawson-Hughes, J. M Ordovas, P. A Price, M. K Williamson, and S. L Booth Vitamin K supplementation and progression of coronary artery calcium in older men and women Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1799 - 1807. [Abstract] [Full Text] [PDF] R. Westenfeld, C. Schafer, T. Kruger, C. Haarmann, L. J. Schurgers, C. Reutelingsperger, O. Ivanovski, T. Drueke, Z. A. Massy, M. Ketteler, et al. Fetuin-A Protects against Atherosclerotic Calcification in CKD J. Am. Soc. Nephrol., June 1, 2009; 20(6): 1264 - 1274. [Abstract] [Full Text] [PDF] Q. Li, L. J. Schurgers, A. C.M. Smith, M. Tsokos, J. Uitto, and E. W. Cowen Co-Existent Pseudoxanthoma Elasticum and Vitamin K-Dependent Coagulation Factor Deficiency: Compound Heterozygosity for Mutations in the GGCX Gene Am. J. Pathol., February 1, 2009; 174(2): 534 - 540. [Abstract] [Full Text] [PDF] X. Fu, X.-D. Wang, H. Mernitz, R. Wallin, M. K. Shea, and S. L. Booth 9-Cis Retinoic Acid Reduces 1{alpha},25-Dihydroxycholecalciferol-Induced Renal Calcification by Altering Vitamin K-Dependent {gamma}-Carboxylation of Matrix {gamma}-Carboxyglutamic Acid Protein in A/J Male Mice J. Nutr., December 1, 2008; 138(12): 2337 - 2341. [Abstract] [Full Text] [PDF] L. L. Demer and Y. Tintut Vascular Calcification: Pathobiology of a Multifaceted Disease Circulation, June 3, 2008; 117(22): 2938 - 2948. [Full Text] [PDF] M. Teichert, L.E. Visser, R.H.N. van Schaik, A. Hofman, A.G. Uitterlinden, P.A.G. M. De Smet, J.C.M. Witteman, and B.H.Ch. Stricker Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism and Aortic Calcification: The Rotterdam Study Arterioscler Thromb Vasc Biol, April 1, 2008; 28(4): 771 - 776. [Abstract] [Full Text] [PDF] M. J. H. van Summeren, W. G. M. Spliet, A. van Royen-Kerkhof, C. Vermeer, M. Lilien, W. Kuis, and L. J. Schurgers Calcinosis in juvenile dermatomyositis: a possible role for the vitamin K-dependent protein matrix Gla protein Rheumatology, March 1, 2008; 47(3): 267 - 271. [Abstract] [Full Text] [PDF] D. A. Towler Vascular Calcification: A Perspective On An Imminent Disease Epidemic IBMS BoneKEy, February 1, 2008; 5(2): 41 - 58. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020