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Blood, 1 May 2007, Vol. 109, No. 9, pp. 4089-4096. Prepublished online as a Blood First Edition Paper on January 18, 2007; DOI 10.1182/blood-2006-08-043935. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-08-043935v1 109/9/4089    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van Bergen, C. A. M. Articles by Falkenburg, J. H. F. Search for Related Content PubMed PubMed Citation Articles by van Bergen, C. A. M. Articles by Falkenburg, J. H. F. Related Collections Immunobiology Neoplasia Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Multiple myeloma–reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene Cornelis A. M. van Bergen1, Michel G. D. Kester1, Inge Jedema1, Mirjam H. M. Heemskerk1, Simone A. P. van Luxemburg-Heijs1, Freke M. Kloosterboer1, W. A. Erik Marijt1, Arnoud H. de Ru2, M. Ron Schaafsma3, Roel Willemze1, Peter A. van Veelen2, and J. H. Frederik Falkenburg1 1 Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, The Netherlands; 2 Department of Immunohematology and Blood Transfusion, Centre for Medical Systems Biology, Leiden University Medical Center, The Netherlands; 3 Medisch Spectrum Twente, Enschede, The Netherlands Minor histocompatibility antigens (mHags) play an important role in both graft-versus-tumor effects and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. We applied biochemical techniques and mass spectrometry to identify the peptide recognized by a dominant tumor-reactive donor T-cell reactivity isolated from a patient with relapsed multiple myeloma who underwent transplantation and entered complete remission after donor lymphocyte infusion. A frequently occurring single nucleotide polymorphism in the human ATP-dependent interferon-responsive (ADIR) gene was found to encode the epitope we designated LB-ADIR-1F. Although gene expression could be found in cells from hematopoietic as well as nonhematopoietic tissues, the patient suffered from only mild acute GVHD despite high percentages of circulating LB-ADIR-1F–specific T cells. Differential recognition of nonhematopoietic cell types and resting hematopoietic cells as compared with activated B cells, T cells, and tumor cells was demonstrated, illustrating variable LB-ADIR-1F expression depending on the cellular activation state. In conclusion, the novel mHag LB-ADIR-1F may be a suitable target for cellular immunotherapy when applied under controlled circumstances. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. N. Stumpf, E. D. van der Meijden, C. A. M. van Bergen, R. Willemze, J. H. F. Falkenburg, and M. Griffioen Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity Blood, October 22, 2009; 114(17): 3684 - 3692. [Abstract] [Full Text] [PDF] D. S. DeLuca, B. Eiz-Vesper, N. Ladas, B. A.-M. Khattab, and R. Blasczyk High-throughput minor histocompatibility antigen prediction Bioinformatics, September 15, 2009; 25(18): 2411 - 2417. [Abstract] [Full Text] [PDF] R. M. Spaapen, H. M. Lokhorst, K. van den Oudenalder, B. E. Otterud, H. Dolstra, M. F. Leppert, M. C. Minnema, A. C. Bloem, and T. Mutis Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel genome-wide analysis J. Exp. Med., November 24, 2008; 205(12): 2863 - 2872. [Abstract] [Full Text] [PDF] M. Griffioen, H.M. E. van Egmond, H. Barnby-Porritt, M. A.W.G. van der Hoorn, R. S. Hagedoorn, M. G.D. Kester, N. Schwabe, R. Willemze, J.H. F. Falkenburg, and M. H.M. Heemskerk Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application Haematologica, October 1, 2008; 93(10): 1535 - 1543. [Abstract] [Full Text] [PDF] T. Kawase, Y. Nannya, H. Torikai, G. Yamamoto, M. Onizuka, S. Morishima, K. Tsujimura, K. Miyamura, Y. Kodera, Y. Morishima, et al. Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA Blood, March 15, 2008; 111(6): 3286 - 3294. [Abstract] [Full Text] [PDF] M. Griffioen, E. D. van der Meijden, E. H. Slager, M. W. Honders, C. E. Rutten, S. A. P. van Luxemburg-Heijs, P. A. von dem Borne, J. J. van Rood, R. Willemze, and J. H. F. Falkenburg Identification of phosphatidylinositol 4-kinase type II {beta} as HLA class II-restricted target in graft versus leukemia reactivity PNAS, March 11, 2008; 105(10): 3837 - 3842. [Abstract] [Full Text] [PDF]

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