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Blood, 1 July 2007, Vol. 110, No. 1, pp. 180-185. Prepublished online as a Blood First Edition Paper on February 8, 2007; DOI 10.1182/blood-2006-11-060087. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-11-060087v1 110/1/180    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tsushima, F. Articles by Chen, L. Search for Related Content PubMed PubMed Citation Articles by Tsushima, F. Articles by Chen, L. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy Fumihiko Tsushima1, Sheng Yao1, Tahiro Shin1, Andrew Flies1, Sarah Flies1, Haiying Xu1, Koji Tamada1, Drew M. Pardoll2, and Lieping Chen1,2 1 Department of Dermatology and 2 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD Although self-reactive T-cell precursors can be eliminated upon recognition of self-antigen presented in the thymus, this central tolerance process is often incomplete, and additional mechanisms are required to prevent autoimmunity. Recent studies indicates that the interaction between B7-H1 and its receptor PD-1 on activated T cells plays an important role in the inhibition of T-cell responses in peripheral organs. Here, we show that, before their exit to the periphery, T cells in lymphoid organs rapidly up-regulate PD-1 upon tolerogen recognition. Ablation of the B7-H1 and PD-1 interaction when T cells are still in lymphoid organs prevents anergy. Furthermore, blockade of B7-H1 and PD-1 interaction could render anergic T cells responsive to antigen. Our results thus reveal previously unappreciated roles of B7-H1 and PD-1 interaction in the control of initiation and reversion of T-cell anergy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. N. Rivas, K. Weatherly, M. Hazzan, B. Vokaer, S. Dremier, F. Gaudray, M. Goldman, I. Salmon, and M. Y. Braun Reviving Function in CD4+ T Cells Adapted to Persistent Systemic Antigen J. Immunol., October 1, 2009; 183(7): 4284 - 4291. [Abstract] [Full Text] [PDF] R. A. Wilcox, A. L. Feldman, D. A. Wada, Z.-Z. Yang, N. I. Comfere, H. Dong, E. D. Kwon, A. J. Novak, S. N. 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