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Blood, 1 December 2007, Vol. 110, No. 12, pp. 3827-3832. Prepublished online as a Blood First Edition Paper on August 31, 2007; DOI 10.1182/blood-2006-12-061408. This Article Full Text Full Text (PDF) Supplemental Figure Erratum (v112,p1546) All Versions of this Article: blood-2006-12-061408v1 110/12/3827    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Piper, K. P. Articles by Moss, P. A. H. Search for Related Content PubMed PubMed Citation Articles by Piper, K. P. Articles by Moss, P. A. H. Related Collections Transplantation Free Research Articles Stem Cells in Hematology Review Articles Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation Karen P. Piper1, Claire Horlock1, S. John Curnow2, Julie Arrazi3, Sarah Nicholls1, Premini Mahendra3, Charles Craddock3, and Paul A. H. Moss1 1 Cancer Research United Kingdom (CRUK) Institute for Cancer Studies and 2 Institute for Biomedical Research, University of Birmingham, Edgbaston, Birmingham; 3 Bone Marrow Transplant Unit, University Hospital Birmingham National Health Service (NHS) Trust, Birmingham, United Kingdom Acute graft-versus-host disease (aGVHD) remains a serious complication following allogeneic stem-cell transplantation (SCT), and is mediated by infiltration of alloreactive donor T cells into recipient tissue. Chemokines and their receptors play a central role in controlling the recruitment of T cells into discrete tissue sites, and determine the clinical features of GVHD in murine models. In this study, we have analyzed the serum concentration of molecules that control leukocyte migration in serial samples from 34 patients following allogeneic SCT. The chemokine CXCL10 (IP-10) was significantly elevated (> 2-fold) in serum at the time of aGVHD. Because the ligand for CXCL10 is CXCR3, the number of CXCR3+ T cells was determined in peripheral blood, but was not increased during episodes of GVHD. To investigate the role of chemokines in the recruitment of T cells to the anatomic site of GVHD, skin biopsies were stained for CXCL10 and CXCR3 expression. CXCL10 expression was observed in the basal keratinocytes of the epidermis in patients with GVHD together with positive staining for CXCR3 on cells in dermal infiltrates. These findings indicate that CXCL10 plays a central role in the pathogenesis of skin aGVHD by the recruitment of CXCR3+ T cells to the sites of inflammation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Mohty, R. M. Szydlo, A. S. M. Yong, J. F. Apperley, J. M. Goldman, and J. V. Melo Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia Blood, September 1, 2008; 112(5): 2163 - 2166. [Abstract] [Full Text] [PDF]

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