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 Blood, 1 December 2007, Vol. 110, No. 12, pp. 3978-3984.
Prepublished online as a Blood First Edition Paper on August 24, 2007; DOI 10.1182/blood-2007-05-091306.

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IMMUNOBIOLOGY

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

Silke F. Fischer1, Philippe Bouillet1, Kristy O'Donnell1, Amanda Light1, David M. Tarlinton1, and Andreas Strasser1

1 The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

T cell–dependent B-cell immune responses induce germinal centers that are sites for expansion, diversification, and selection of antigen-specific B cells. During the immune response, antigen-specific B cells are removed in a process that favors the retention of cells with improved affinity for antigen, a cell death process inhibited by excess Bcl-2. In this study, we examined the role of the BH3-only protein Bim, an initiator of apoptosis in the Bcl-2–regulated pathway, in the programmed cell death accompanying an immune response. After immunization, Bim-deficient mice showed persistence of both memory B cells lacking affinity-enhancing mutations in their immunoglobulin genes and antibody-forming cells secreting low-affinity antibodies. This was accompanied by enhanced survival of both cell types in culture. We have identified for the first time the physiologic mechanisms for killing low-affinity antibody-expressing B cells in an immune response and have shown this to be dependent on the BH3-only protein Bim.


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