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Blood, 1 August 2007, Vol. 110, No. 3, pp. 908-912. Prepublished online as a Blood First Edition Paper on April 4, 2007; DOI 10.1182/blood-2006-11-057604. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-11-057604v1 110/3/908    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Austin, H. Articles by Hooper, W. C. Search for Related Content PubMed PubMed Citation Articles by Austin, H. Articles by Hooper, W. C. Related Collections Hemostasis, Thrombosis, and Vascular Biology Red Cells Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Sickle cell trait and the risk of venous thromboembolism among blacks Harland Austin1, Nigel S. Key2, Jane M. Benson3, Cathy Lally1, Nicole F. Dowling3, Carolyn Whitsett4, and W. Craig Hooper3 1 Emory University, Rollins School of Public Health, Atlanta, GA; 2 University of North Carolina, Chapel Hill; 3 Division of Hereditary Blood Disorders, Centers for Disease Control and Prevention, Atlanta, GA; 4 Emory University, School of Medicine, Atlanta, GA People with sickle cell disease have a chronically activated coagulation system and display hemostatic perturbations, but it is unknown whether they experience an increased risk of venous thromboembolism. We conducted a case–control study of venous thromboembolism that included 515 hospitalized black patients and 555 black controls obtained from medical clinics. All subjects were assayed for hemoglobin S and hemoglobin C genotypes. The prevalence of the S allele was 0.070 and 0.032 for case patients and controls, respectively (P < .001). The odds that a patient had sickle cell trait were approximately twice that of a control, indicating that the risk of venous thromboembolism is increased approximately 2-fold among blacks with sickle cell trait compared with those with the wild-type genotype (odds ratio = 1.8 with 95% confidence interval, 1.2-2.9). The odds ratio for pulmonary embolism and sickle cell trait was higher, 3.9 (2.2-6.9). The prevalence of sickle cell disease was also increased among case patients compared with controls. We conclude that sickle cell trait is a risk factor for venous thromboembolism and that the proportion of venous thromboembolism among blacks attributable to the mutation is approximately 7%. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. S. Adam, N. S. Key, and C. S. Greenberg D-dimer antigen: current concepts and future prospects Blood, March 26, 2009; 113(13): 2878 - 2887. [Abstract] [Full Text] [PDF] S. S. Adam, G. Zaher, M. Ibrahim, K. I Ataga, L. M. De Castro, and N. S. Key Markers of Coagulation Activation and Inflammation in Sickle Cell Disease and Sickle Cell Trait Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 4813 - 4813. [Abstract] M. G. Beckman, S. E. Critchley, W. C. Hooper, A. M. Grant, and R. Kulkarni CDC Division of Blood Disorders: Public Health Research Activities in Venous Thromboembolism Arterioscler Thromb Vasc Biol, March 1, 2008; 28(3): 394 - 395. [Full Text] [PDF] Venous Thrombosis in Patients with Sickle Cell Trait Journal Watch Oncology and Hematology, August 21, 2007; 2007(821): 2 - 2. [Full Text] K. I. Ataga and N. S. Key Hypercoagulability in Sickle Cell Disease: New Approaches to an Old Problem Hematology, January 1, 2007; 2007(1): 91 - 96. [Abstract] [Full Text] [PDF]

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