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Blood, 15 August 2007, Vol. 110, No. 4, pp. 1330-1333. Prepublished online as a Blood First Edition Paper on May 11, 2007; DOI 10.1182/blood-2007-03-081133. This Article Full Text Full Text (PDF) Supplemental Methods, Tables, and Figures All Versions of this Article: blood-2007-03-081133v1 110/4/1330    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Löffler, D. Articles by Horn, F. Search for Related Content PubMed PubMed Citation Articles by Löffler, D. Articles by Horn, F. Related Collections Neoplasia Signal Transduction Gene Expression Brief Reports Chemokines, Cytokines, and Interleukins Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief Report Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer Dennis Löffler1,5, Katja Brocke-Heidrich1,5, Gabriele Pfeifer1, Claudia Stocsits2, Jörg Hackermüller3, Antje K. Kretzschmar3, Renate Burger4, Martin Gramatzki4, Conny Blumert1, Kay Bauer1,5, Helena Cvijic1, A. Kerstin Ullmann1, Peter F. Stadler2,3, and Friedemann Horn1,3,5 1 Institute of Clinical Immunology and Transfusion Medicine, Medical Faculty, University of Leipzig, Leipzig; 2 Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig; 3 Fraunhofer Institute of Cell Therapy and Immunology, Leipzig; 4 Division of Stem Cell Transplantation and Immunotherapy, 2nd Medical Department, University Hospital Schleswig-Holstein Campus Kiel, Kiel; 5 Interdisciplinary Center for Clinical Studies, University of Leipzig, Germany Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6–dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing 2 Stat3 binding sites strictly conserved since the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was strictly Stat3 dependent. Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: The STATus of miR-21 in apoptosis Elaine M. Hurt and William L. Farrar Blood 2007 110: 1086-1087. [Full Text] [PDF] This article has been cited by other articles: M. V. Iorio and C. M. Croce MicroRNAs in Cancer: Small Molecules With a Huge Impact J. Clin. Oncol., December 1, 2009; 27(34): 5848 - 5856. [Abstract] [Full Text] [PDF] G. A. Calin and C. M. Croce Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes Blood, November 26, 2009; 114(23): 4761 - 4770. [Abstract] [Full Text] [PDF] E. A. Mathe, G. H. Nguyen, E. D. Bowman, Y. Zhao, A. Budhu, A. J. 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