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Blood, 15 August 2007, Vol. 110, No. 4, pp. 1397-1400. Prepublished online as a Blood First Edition Paper on May 2, 2007; DOI 10.1182/blood-2007-03-081596. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-03-081596v1 110/4/1397    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schrezenmeier, H. Articles by Eapen, M. Search for Related Content PubMed PubMed Citation Articles by Schrezenmeier, H. Articles by Eapen, M. Related Collections Hematopoiesis and Stem Cells Transplantation Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents TRANSPLANTATION Brief Report Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia Hubert Schrezenmeier1, Jakob R. Passweg2, Judith C. W. Marsh3, Andrea Bacigalupo4, Christopher N. Bredeson5, Eduardo Bullorsky6, Bruce M. Camitta5, Richard E. Champlin7, Robert Peter Gale8, Monika Fuhrer9, John P. Klein10, Anna Locasciulli11, Rosi Oneto4, Antonius V. M. B. Schattenberg12, Gerard Socie13, and Mary Eapen10 1 Institute of Clinical Transfusion Medicine and Immunogenetics, University of Ulm, Germany; 2 Hopitaux Universitaires, Geneva, Switzerland; 3 St George's Hospital Medical School, London, United Kingdom 4 Ospedale S. Martino, Genova, Italy; 5 Medical College of Wisconsin, Milwaukee; 6 Hospital Britanico, Buenos Aires, Argentina; 7 M. D. Anderson Cancer Center, Houston, TX; 8 Center for Advanced Studies in Leukemia, Los Angeles, CA; 9 Universitat Munchen, Munich, Germany; 10 The Statistical Center, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; 11 Ospedale S. Camillo-Forlanini, Rome, Italy; 12 University Medical Center, Nijmegen, the Netherlands; 13 St Louis Hospital-1, Paris, France We analyzed the outcome of 692 patients with severe aplastic anemia (SAA) receiving transplants from HLA-matched siblings. A total of 134 grafts were peripheral blood progenitor cell (PBPC) grafts, and 558 were bone marrow (BM) grafts. Rates of hematopoietic recovery and grades 2 to 4 chronic graft-versus-host disease (GVHD) were similar after PBPC and BM transplantations regardless of age at transplantation. In patients older than 20 years, chronic GVHD and overall mortality rates were similar after PBPC and BM transplantations. In patients younger than 20 years, rates of chronic GVHD (relative risk [RR] 2.82; P = .002) and overall mortality (RR 2.04; P = .024) were higher after transplantation of PBPCs than after transplantation of BM. In younger patients, the 5-year probabilities of overall survival were 73% and 85% after PBPC and BM transplantations, respectively. Corresponding probabilities for older patients were 52% and 64%. These data indicate that BM grafts are preferred to PBPC grafts in young patients undergoing HLA-matched sibling donor transplantation for SAA. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. J. Lee, S. Joffe, A. S. Artz, R. E. Champlin, S. M. Davies, M. Jagasia, N. A. Kernan, F. R. Loberiza Jr, R. J. Soiffer, and M. Eapen Individual Physician Practice Variation in Hematopoietic Cell Transplantation J. Clin. Oncol., May 1, 2008; 26(13): 2162 - 2170. [Abstract] [Full Text] [PDF] A. Bacigalupo Aplastic Anemia: Pathogenesis and Treatment Hematology, January 1, 2007; 2007(1): 23 - 28. [Abstract] [Full Text] [PDF]

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