SEARCH:   Advanced

Blood, 1 September 2007, Vol. 110, No. 5, pp. 1540-1549. Prepublished online as a Blood First Edition Paper on May 4, 2007; DOI 10.1182/blood-2006-11-056010. This Article Full Text Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2006-11-056010v1 110/5/1540    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tas, S. W. Articles by de Jong, E. C. Search for Related Content PubMed PubMed Citation Articles by Tas, S. W. Articles by de Jong, E. C. Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Noncanonical NF-B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation Sander W. Tas1, Margriet J. Vervoordeldonk1, Najat Hajji1, Joost H. N. Schuitemaker2, Koen F. van der Sluijs3, Michael J. May4, Sankar Ghosh5, Martien L. Kapsenberg2, Paul P. Tak1, and Esther C. de Jong2 1 Division of Clinical Immunology and Rheumatology, 2 Department of Cell Biology and Histology, and 3 Department of Experimental Immunology, Academic Medical Center (AMC)/University of Amsterdam, Amsterdam, the Netherlands; 4 School of Veterinary Medicine, Department of Animal Biology, University of Pennsylvania, Philadelphia; 5 Immunobiology Section, Yale University Medical School, New Haven, CT Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators via canonical NF-B signaling, as well as late expression of the anti-inflammatory enzyme indoleamine 2,3-dioxygenase (IDO) via unknown signal transduction. By selective blocking of either the canonical NF-B pathway using the NEMO-binding domain peptide or the noncanonical NF-B pathway by small interfering RNA, we demonstrate that IDO expression requires noncanonical NF-B signaling. Also, noncanonical NF-B signaling down-regulates proinflammatory cytokine production in DCs. In addition, selective activation of the noncanonical NF-B pathway results in noninflammatory DCs that suppress T-cell activation and promote the development of T cells with regulatory properties. These findings reveal an important role of the noncanonical NF-B pathway in the regulation of immunity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. H. Kim, B. K. Choi, W. J. Kang, K. H. Kim, S. W. Kang, A. L. Mellor, D. H. Munn, and B. S. Kwon IFN-{gamma}-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo J. Leukoc. Biol., May 1, 2009; 85(5): 817 - 825. [Abstract] [Full Text] [PDF] A. Curti, S. Trabanelli, V. Salvestrini, M. Baccarani, and R. M. Lemoli The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology Blood, March 12, 2009; 113(11): 2394 - 2401. [Abstract] [Full Text] [PDF] Y.-I. Jeong, S. W. Kim, I. D. Jung, J. S. Lee, J. H. Chang, C.-M. Lee, S. H. Chun, M.-S. Yoon, G. T. Kim, S. W. Ryu, et al. Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase C{delta}-STAT1 Signaling Pathway in Interferon-{gamma}-stimulated Murine Dendritic Cells J. Biol. Chem., February 6, 2009; 284(6): 3700 - 3708. [Abstract] [Full Text] [PDF] M.-C. Yen, C.-C. Lin, Y.-L. Chen, S.-S. Huang, H.-J. Yang, C.-P. Chang, H.-Y. Lei, and M.-D. Lai A Novel Cancer Therapy by Skin Delivery of Indoleamine 2,3-Dioxygenase siRNA Clin. Cancer Res., January 15, 2009; 15(2): 641 - 649. [Abstract] [Full Text] [PDF] C. Orabona, M. T. Pallotta, C. Volpi, F. Fallarino, C. Vacca, R. Bianchi, M. L. Belladonna, M. C. Fioretti, U. Grohmann, and P. Puccetti SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis PNAS, December 30, 2008; 105(52): 20828 - 20833. [Abstract] [Full Text] [PDF] M. L. Belladonna, C. Volpi, R. Bianchi, C. Vacca, C. Orabona, M. T. Pallotta, L. Boon, S. Gizzi, M. C. Fioretti, U. Grohmann, et al. Cutting Edge: Autocrine TGF-{beta} Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells J. Immunol., October 15, 2008; 181(8): 5194 - 5198. [Abstract] [Full Text] [PDF] W. Chen, X. Liang, A. J. Peterson, D. H. Munn, and B. R. Blazar The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation J. Immunol., October 15, 2008; 181(8): 5396 - 5404. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020