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Blood, 15 September 2007, Vol. 110, No. 6, pp. 1933-1941. Prepublished online as a Blood First Edition Paper on May 15, 2007; DOI 10.1182/blood-2006-09-048322. This Article Full Text Full Text (PDF) Supplemental Methods All Versions of this Article: blood-2006-09-048322v1 110/6/1933    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gutiérrez, L. Articles by Lambrecht, B. N. Search for Related Content PubMed PubMed Citation Articles by Gutiérrez, L. Articles by Lambrecht, B. N. Related Collections Hematopoiesis and Stem Cells Immunobiology Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Gata1 regulates dendritic-cell development and survival Laura Gutiérrez1, Tatjana Nikolic2, Thamar B. van Dijk1, Hamida Hammad2, Nanda Vos2, Monique Willart2, Frank Grosveld1, Sjaak Philipsen1, and Bart N. Lambrecht2 1 Departments of Cell Biology and 2 Pulmonary Medicine, Erasmus Medical Center (MC), Rotterdam, The Netherlands Dendritic cells are key initiators and regulators of the immune response. Dendritic cell commitment and function require orchestrated regulation of transcription. Gata1 is a transcription factor expressed in several hematopoietic lineages. However, Gata1 function has not been explored in the monocytic or dendritic cell compartment. Here, we show that Gata1 is expressed in myeloid and plasmacytoid dendritic cells and that Gata1 ablation affects the survival of dendritic cells. Furthermore, lipopolysaccharide (LPS) stimulation of dendritic cells prompts Gata1 up-regulation, which is accompanied by increased levels of BclX and Ifng. Our findings show that Gata1 is a transcriptional regulator of dendritic cell differentiation and suggest that Gata1 is involved in the dendritic cell and macrophage lineage separation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Ohneda, S. Ohmori, Y. Ishijima, M. Nakano, and M. Yamamoto Characterization of a Functional ZBP-89 Binding Site That Mediates Gata1 Gene Expression during Hematopoietic Development J. Biol. Chem., October 30, 2009; 284(44): 30187 - 30199. [Abstract] [Full Text] [PDF] F. Gobel, S. Taschner, J. Jurkin, S. Konradi, C. Vaculik, S. Richter, D. Kneidinger, C. Muhlbacher, C. Bieglmayer, A. Elbe-Burger, et al. Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation Blood, October 29, 2009; 114(18): 3813 - 3821. [Abstract] [Full Text] [PDF] M. Suzuki, T. Moriguchi, K. Ohneda, and M. Yamamoto Differential Contribution of the Gata1 Gene Hematopoietic Enhancer to Erythroid Differentiation Mol. Cell. Biol., March 1, 2009; 29(5): 1163 - 1175. [Abstract] [Full Text] [PDF] Y. Cheng, D. C. King, L. C. Dore, X. Zhang, Y. Zhou, Y. Zhang, C. Dorman, D. Abebe, S. A. Kumar, F. Chiaromonte, et al. Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif Genome Res., December 1, 2008; 18(12): 1896 - 1905. [Abstract] [Full Text] [PDF] C. S. McKimmie, A. R. Fraser, C. Hansell, L. Gutierrez, S. Philipsen, L. Connell, A. Rot, M. Kurowska-Stolarska, P. Carreno, M. Pruenster, et al. Hemopoietic Cell Expression of the Chemokine Decoy Receptor D6 Is Dynamic and Regulated by GATA1 J. Immunol., September 1, 2008; 181(5): 3353 - 3363. [Abstract] [Full Text] [PDF]

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