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Blood, 1 October 2007, Vol. 110, No. 7, pp. 2586-2592. Prepublished online as a Blood First Edition Paper on June 18, 2007; DOI 10.1182/blood-2007-05-088443. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-05-088443v1 110/7/2586    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pérez-Persona, E. Articles by San Miguel, J. F. Search for Related Content PubMed PubMed Citation Articles by Pérez-Persona, E. Articles by San Miguel, J. F. Related Collections Immunobiology Neoplasia Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells Ernesto Pérez-Persona1, María-Belén Vidriales1,2, Gema Mateo1, Ramón García-Sanz1,2, Maria-Victoria Mateos1, Alfonso García de Coca3, Josefina Galende4, Guillermo Martín-Nuñez5, José M. Alonso6, Natalia de las Heras7, José M. Hernández8, Alejandro Martín9, Consuelo López-Berges1, Alberto Orfao2,10, and Jesús F. San Miguel1,2 1 Department of Hematology, University Hospital, Salamanca; 2 Centro de Investigación del Cancer, Universidad de Salamanca/Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca; 3 Department of Hematology, University Hospital, Valladolid; 4 Department of Hematology, Hospital Comarcal del Bierzo, Ponferrada, León; 5 Department of Hematology, Hospital Nuestra Señora del Puerto de Plasencia, Cáceres; 6 Department of Hematology, Hospital Río Carrión, Palencia, Caceres; 7 Department of Hematology, Complejo Hospitalario, León; 8 Department of Hematology, General Hospital, Segovia; 9 Department of Hematology, Hospital Virgen de la Concha, Zamora; and 10 Department of Cytometry, University of Salamanca, Salamanca, Spain Monoclonal gammopathy of uncertain significance (MGUS) and smoldering multiple myeloma (SMM) are plasma cell disorders with a risk of progression of approximately 1% and 10% per year, respectively. We have previously shown that the proportion of bone marrow (BM) aberrant plasma cells (aPCs) within the BMPC compartment (aPC/BMPC) as assessed by flow cytometry (FC) contributes to differential diagnosis between MGUS and multiple myloma (MM). The goal of the present study was to investigate this parameter as a marker for risk of progression in MGUS (n = 407) and SMM (n = 93). Patients with a marked predominance of aPCs/BMPC ( 95%) at diagnosis displayed a significantly higher risk of progression both in MGUS and SMM (P< .001). Multivariate analysis for progression-free survival (PFS) selected the percentage aPC/BMPC ( 95%) as the most important independent variable, together with DNA aneuploidy and immunoparesis, for MGUS and SMM, respectively. Using these independent variables, we have identified 3 risk categories in MGUS (PFS at 5 years of 2%, 10%, and 46%, respectively; P< .001) and SMM patients (PFS at 5 years of 4%, 46%, and 72%, respectively; P < .001). Our results show that multiparameter FC evaluation of BMPC at diagnosis is a valuable tool that could help to individualize the follow-up strategy for MGUS and SMM patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Progression risk for MGUS and SMM Philip Greipp Blood 2007 110: 2226. [Full Text] [PDF] This article has been cited by other articles: G. Mateo, M. A. Montalban, M.-B. Vidriales, J. J. Lahuerta, M. V. Mateos, N. Gutierrez, L. Rosinol, L. Montejano, J. Blade, R. Martinez, et al. Prognostic Value of Immunophenotyping in Multiple Myeloma: A Study by the PETHEMA/GEM Cooperative Study Groups on Patients Uniformly Treated With High-Dose Therapy J. Clin. Oncol., June 1, 2008; 26(16): 2737 - 2744. [Abstract] [Full Text] [PDF] A. C. Rawstron, A. Orfao, M. Beksac, L. Bezdickova, R. A. Brooimans, H. Bumbea, K. Dalva, G. Fuhler, J. Gratama, D. Hose, et al. Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders Haematologica, March 1, 2008; 93(3): 431 - 438. [Abstract] [Full Text] [PDF] J. Blade and L. Rosinol SMM: toward better predictors of progression Blood, January 15, 2008; 111(2): 479 - 480. [Full Text] [PDF]

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