Blood, 15 May 2008, Vol. 111, No. 10, pp. 4862-4870.
Prepublished online as a Blood First Edition Paper on March 11, 2008; DOI 10.1182/blood-2007-12-127662.
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REVIEW IN TRANSLATIONAL HEMATOLOGY
Beyond the increasing complexity of the immunomodulatory HLA-G molecule
Edgardo D. Carosella1,
Benoit Favier1,
Nathalie Rouas-Freiss1,
Philippe Moreau1, and
Joel LeMaoult1
1 CEA, I2BM, Service de Recherches en Hemato-Immunologie, Paris, France
Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.
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