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Blood, 15 June 2008, Vol. 111, No. 12, pp. 5433-5439. Prepublished online as a Blood First Edition Paper on February 13, 2008; DOI 10.1182/blood-2007-11-124792. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-11-124792v1 111/12/5433    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Feldman, A. L. Articles by Jaffe, E. S. Search for Related Content PubMed PubMed Citation Articles by Feldman, A. L. Articles by Jaffe, E. S. Related Collections Neoplasia Plenary Papers Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PLENARY PAPER Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone Andrew L. Feldman1,2, Daniel A. Arber3, Stefania Pittaluga1, Antonio Martinez4, Jerome S. Burke5, Mark Raffeld1, Mireia Camos4, Roger Warnke3, and Elaine S. Jaffe1 1 Laboratory of Pathology, National Cancer Institute, Bethesda, MD; 2 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; 3 Department of Pathology, Stanford University, Stanford, CA; 4 University of Barcelona, Barcelona, Spain; and 5 Department of Pathology, Alta Bates Summit Medical Center, Berkeley, CA Rare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown. We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements. There were 5 men and 3 women (median age, 59 years). All cases of FL were positive for t(14;18). The H/DC tumors included 7 histiocytic sarcomas, 5 of which showed evidence of dendritic differentiation, and 1 interdigitating cell sarcoma. Five H/DC tumors were metachronous, following FL by 2 months to 12 years; tumors were synchronous in 3. All 8 H/DC tumors showed presence of the t(14;18) either by FISH, or in 2 cases by PCR with the major breakpoint region (MBR) probe. PCR and sequencing identified identical IGH gene rearrangements or BCL2 gene breakpoints in all patients tested. All H/DC tumors lacked PAX5, and up-regulation of CEBPβ and PU.1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Follicular lymphomas and histiocytic/dendritic neoplasms related? Jonathan Said Blood 2008 111: 5418-5419. [Full Text] [PDF] This article has been cited by other articles: E. S. Jaffe, N. L. Harris, H. Stein, and P. G. Isaacson Classification of lymphoid neoplasms: the microscope as a tool for disease discovery Blood, December 1, 2008; 112(12): 4384 - 4399. [Abstract] [Full Text] [PDF]

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