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Blood, 15 June 2008, Vol. 111, No. 12, pp. 5496-5504. Prepublished online as a Blood First Edition Paper on April 2, 2008; DOI 10.1182/blood-2008-01-134270. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2008-01-134270v1 111/12/5496    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Savage, K. J. Articles by Weisenburger, D. D. Search for Related Content PubMed PubMed Citation Articles by Savage, K. J. Articles by Weisenburger, D. D. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS ALK– anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project Kerry J. Savage1, Nancy Lee Harris2, Julie M. Vose3, Fred Ullrich4, Elaine S. Jaffe5, Joseph M. Connors1, Lisa Rimsza6, Stefano A. Pileri7, Mukesh Chhanabhai8, Randy D. Gascoyne8, James O. Armitage3, Dennis D. Weisenburger, for the International Peripheral T-Cell Lymphoma Project9 1 Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC; 2 Department of Pathology, Massachusetts General Hospital, Boston; Departments of3 Internal Medicine and 4 Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha; 5 Department of Hematopathology, National Cancer Institute, Bethesda, MD; 6 Department of Pathology, University of Arizona, Tucson; 7 Department of Pathology, Bologna University School of Medicine, Bologna, Italy; 8 Department of Pathology, British Columbia Cancer Agency, Vancouver, BC; and 9 Department of Pathology, University of Nebraska Medical Center, Omaha The International Peripheral T-Cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell lymphomas (PTCLs). A total of 22 institutions in North America, Europe, and Asia submitted clinical and pathologic information on PTCLs diagnosed and treated at their respective centers. Of the 1314 eligible patients, 181 had anaplastic large-cell lymphoma (ALCL; 13.8%) on consensus review: One hundred fifty-nine had systemic ALCL (12.1%) and 22 had primary cutaneous ALCL (1.7%). Patients with anaplastic lymphoma kinase–positive (ALK+) ALCL had a superior outcome compared with those with ALK– ALCL (5-year failure-free survival [FFS], 60% vs 36%; P = .015; 5-year overall survival [OS], 70% vs 49%; P = .016). However, contrary to prior reports, the 5-year FFS (36% vs 20%; P = .012) and OS (49% vs 32%; P = .032) were superior for ALK– ALCL compared with PTCL, not otherwise specified (PTCL-NOS). Patients with primary cutaneous ALCL had a very favorable 5-year OS (90%), but with a propensity to relapse (5-year FFS, 55%). In summary, ALK– ALCL should continue to be separated from both ALK+ ALCL and PTCL-NOS. Although the prognosis of ALK– ALCL appears to be better than that for PTCL-NOS, it is still unsatisfactory and better therapies are needed. Primary cutaneous ALCL is associated with an indolent course. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Ambrogio, C. Martinengo, C. Voena, F. Tondat, L. Riera, P. F. di Celle, G. Inghirami, and R. Chiarle NPM-ALK Oncogenic Tyrosine Kinase Controls T-Cell Identity by Transcriptional Regulation and Epigenetic Silencing in Lymphoma Cells Cancer Res., November 15, 2009; 69(22): 8611 - 8619. [Abstract] [Full Text] [PDF] G. Gualco, L. Chioato, L. M. Weiss, W. J. Harrington Jr, and C. E. Bacchi Analysis of Human T-Cell Lymphotropic Virus in CD25+ Anaplastic Large Cell Lymphoma in Children Am J Clin Pathol, July 1, 2009; 132(1): 28 - 33. [Abstract] [Full Text] [PDF] B. Falini and M. P. Martelli Anaplastic large cell lymphoma: changes in the World Health Organization classification and perspectives for targeted therapy Haematologica, July 1, 2009; 94(7): 897 - 900. [Full Text] [PDF] W.-y. Au, D. D. Weisenburger, T. Intragumtornchai, S. Nakamura, W.-S. Kim, I. Sng, J. Vose, J. O. Armitage, R. Liang, and for the International Peripheral T-Cell Lymphoma P Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project Blood, April 23, 2009; 113(17): 3931 - 3937. [Abstract] [Full Text] [PDF] P. Reimer, T. Rudiger, E. Geissinger, F. Weissinger, C. Nerl, N. Schmitz, A. Engert, H. Einsele, H. K. Muller-Hermelink, and M. Wilhelm Autologous Stem-Cell Transplantation As First-Line Therapy in Peripheral T-Cell Lymphomas: Results of a Prospective Multicenter Study J. Clin. Oncol., January 1, 2009; 27(1): 106 - 113. [Abstract] [Full Text] [PDF] A. M. Evens and B. C.-H. Chiu The Challenges of Epidemiologic Research in Non-Hodgkin Lymphoma JAMA, November 5, 2008; 300(17): 2059 - 2061. [Full Text] [PDF] C Agostinelli, P P Piccaluga, P Went, M Rossi, A Gazzola, S Righi, T Sista, C Campidelli, P L Zinzani, B Falini, et al. Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies J. Clin. Pathol., November 1, 2008; 61(11): 1160 - 1167. [Abstract] [Full Text] [PDF] L. de Leval and P. Gaulard Pathobiology and Molecular Profiling of Peripheral T-Cell Lymphomas Hematology, January 1, 2008; 2008(1): 272 - 279. [Abstract] [Full Text] [PDF] K. J. Savage Prognosis and Primary Therapy in Peripheral T-Cell Lymphomas Hematology, January 1, 2008; 2008(1): 280 - 288. [Abstract] [Full Text] [PDF]

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